Document Detail


Relationship of contrast-enhanced magnetic resonance imaging-derived intramural scar distribution and speckle tracking echocardiography-derived left ventricular two-dimensional strains.
MedLine Citation:
PMID:  21965153     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: Information is limited regarding the functional correlates of intramural scar burden in myopathic hearts. We aimed to explore the use of speckle tracking echocardiography selectively at three intramural locations, to investigate the variance in cardiac strains and their relationship to contrast-enhanced magnetic resonance imaging-derived scar distribution and global left ventricular systolic function. METHODS AND RESULTS: Fifty-nine patients with evidence of myocardial fibrosis on contrast-enhanced magnetic resonance imaging and 18 healthy subjects underwent speckle tracking echocardiography for measuring subendocardial, midmyocardial, and subepicardial strains in longitudinal, circumferential, and radial directions. Patients were divided into three categories of scar distribution: Group A, endocardial and midmyocardial; Group B, midmyocardial and epicardial; and Group C, transmural. When these patients were compared with 18 healthy control subjects, longitudinal left ventricular deformation was attenuated equally for all three groups, whereas circumferential strain was relatively well preserved. On multivariate analysis, circumferential strain and scar burden were independent determinants of left ventricular ejection fraction (R(2) = 0.57; P= 0.003 for strain burden and P= 0.01 for scar burden). CONCLUSION: Longitudinal strains are attenuated independent of myocardial scar location. This alteration in left ventricular deformation is associated with circumferential mechanics becoming a key determinant of global left ventricular pump function in myopathic hearts.
Authors:
Mayank M Kansal; Prasad M Panse; Haruhiko Abe; Giuseppe Caracciolo; Susan Wilansky; A Jamil Tajik; Bijoy K Khandheria; Partho P Sengupta
Related Documents :
15196103 - Predictive value of preoperative transthoracic echocardiography in patients undergoing ...
9391293 - Early changes in left ventricular anterior wall dynamics and coordination after coronar...
9417213 - The comparative diagnostic value of dobutamine stress echocardiography and thallium str...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-1
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  -     ISSN:  1532-2114     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Cardiovascular Diseases, University of Illinois at Chicago, Chicago, IL, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Two-dimensional myocardial strain imaging detects changes in left ventricular systolic function imme...
Next Document:  Congenital diaphragmatic hernia in Smith-Magenis syndrome: A possible locus at chromosome 17p11.2.