Document Detail


Relationship of cigarette smoking to blood pressure and serum lipids and lipoproteins in men.
MedLine Citation:
PMID:  8713678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The relationship of cigarette smoking to blood pressure and serum lipids and lipoproteins was studied in 7608 men, ranging from 40 to 59 years of age. Analyses were performed separately for non-drinkers and drinkers. 2. After adjusting age and body mass index (BMI) in non-drinkers and age, BMI and alcohol intake in drinkers in forward stepwise multiple regression analysis, there was a dose-dependent negative relationship between cigarette smoking and diastolic blood pressure (DBP) and high density lipoprotein cholesterol (HDL-C), regardless of drinking habit. There was a dose-dependent positive relationship between cigarette smoking and the ratio of total cholesterol (TC) to HDL-C (TC:HDL-C) in non-drinkers, but not in drinkers. There was a dose-dependent negative relationship between cigarette smoking and TC and a positive relationship between cigarette smoking and triglycerides (TG) in drinkers, but not in non-drinkers. 3. After matching age and BMI in non-drinkers, subjects who smoked more than 30 cigarettes/day had significantly lower mean values of systolic blood pressure (SBP; 4.3%; P < 0.05), DBP (3.0%; P < 0.01) and HDL-C (15.5%; P < 0.01) and higher mean values of TC:HDL-C (25.0%; P < 0.01), TG (46.8%; P < 0.01) and beta-lipoprotein (12.0%; P < 0.01) than non-smokers. In drinkers, after matching age, BMI, and alcohol intake, subjects who smoked more than 30 cigarettes/day had significantly lower mean values of SBP (2.8%; P < 0.05), DBP (4.8%; P < 0.01), HDL-C (17.3%; P < 0.01) and TC (4.4%; P < 0.01) and higher mean values of TC:HDL-C (15.4%; P < 0.01) and TG (45.1%; P < 0.01) than non-smokers. 4. Although the results are somewhat variable, the present study reveals that cigarette smoking is negatively associated with SBP and DBP and unfavourably associated with lipids and lipoproteins, regardless of drinking habit.
Authors:
H Imamura; K Tanaka; C Hirae; T Futagami; Y Yoshimura; K Uchida; A Tanaka; D Kobata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  23     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-01-28     Completed Date:  1997-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  397-402     Citation Subset:  IM    
Affiliation:
Laboratory of Nutrition and Exercise Physiology, Nakamura Gakuen University, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects
Blood Pressure / drug effects*
Cholesterol, HDL / blood,  drug effects
Confounding Factors (Epidemiology)
Humans
Hyperlipidemias / epidemiology*
Hypertension / epidemiology*
Lipids / blood*
Lipoproteins / blood,  drug effects*
Male
Middle Aged
Reproducibility of Results
Smoking / adverse effects*
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Lipids; 0/Lipoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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