| Relationship of cardiac hypertrophy and diastolic dysfunction assessed by echocardiography with atherosclerosis in retinal arteries in hypertensive patients. | |
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MedLine Citation:
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PMID: 18855256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although left ventricular (LV) hypertrophy and diastolic dysfunction assessed by echocardiography are established risk markers of cardiovascular events in hypertensive patients, relationships between these echocardiographic findings and atherosclerosis have not been fully elucidated. The purpose of this study was to examine the relationships between atherosclerosis of the retinal arteries and echocardiographic findings in hypertensive patients. Forty hypertensive patients were divided into two groups according to Scheie's classification by ophthalmologists: 20 patients with stage 1 changes (visible broadening of the light reflex from the artery with minimal arteriovenous compression) and 20 patients with stage 2 changes (more prominent than those in stage 1). Standard echocardiography was performed to measure LV mass index for evaluating LV hypertrophy and conventional diastolic transmitral flow velocities for assessing LV diastolic function. Mitral annular velocities were also measured for evaluating LV diastolic function using tissue Doppler echocardiography. The LV mass index was larger in stage 2 (130 +/- 39 g/m(2)) than stage 1 (96 +/- 16 g/m(2)) patients (p = 0.001). Peak early diastolic mitral annular velocity (E') was lower in stage 2 (5.9 +/- 0.9 cm/s) than stage 1 (7.9 +/- 1.7 cm/s) patients (p = 0.001). The optimal cutoff points for the diagnosis of Scheie stage 2 were 6.6 cm/sec for E' (sensitivity 75%, specificity 85%) and 111 g/m(2) for LV mass index (sensitivity 70%, specificity 90%). In conclusion, in hypertensive patients, the extent of atherosclerosis in the retinal arteries can be estimated by LV hypertrophy and diastolic dysfunction assessed by echocardiography. |
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Authors:
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Hisashi Masugata; Shoichi Senda; Jun Hoshikawa; Ayumu Yamagami; Hiroyuki Okuyama; Masanobu Imai; Kazushi Yukiiri; Masakazu Kohno; Fuminori Goda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: 30 ISSN: 1525-6006 ISO Abbreviation: Clin. Exp. Hypertens. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 520-9 Citation Subset: IM |
Affiliation:
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Department of Integrated Medicine, Kagawa University, Kita-gun, Kagawa, Japan. masugata@med.kagawa-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atherosclerosis / diagnosis, etiology, pathology* Diastole Echocardiography Female Humans Hypertension / complications, pathology, physiopathology, ultrasonography* Hypertrophy, Left Ventricular / physiopathology, ultrasonography* Male Middle Aged Retinal Artery / pathology* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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