Document Detail

Relationship of blood pressure and other factors to serial retinal arteriolar diameter measurements over time: the beaver dam eye study.
MedLine Citation:
PMID:  22893073     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe the relationship of blood pressure (BP), antihypertensive medication use, and other factors to serial measurements of retinal arteriolar diameters over time in the Beaver Dam Eye Study.
METHODS: Retinal arteriolar diameter was measured by computer-assisted methods and summarized as central retinal arteriolar equivalent (CRAE) in 4573 persons aged 43 to 99 years at 4 examinations (each separated by 5 years) during a 15-year period. Associations of CRAE with risk factors measured concurrently and 5 years previously were determined using multivariate analyses.
RESULTS: While adjusting for image quality, refraction, and lens status, age (per 10 years: β estimate, -0.73; P < .001), systolic BP (per 10 mm Hg: concurrent examination, -2.74; P < .001; previous examination, -1.75; P < .001), smoking status (smoker vs nonsmoker: concurrent examination, 4.29; P < .001; previous examination, 1.63; P = .004), body mass index (per category: concurrent examination, -0.51; P = .05; previous examination, -0.22; P = .44), and heavy alcohol consumption (drinking) (current vs past/never heavy drinker: concurrent examination, -2.54; P = .03; previous examination, -2.42; P = .02) were associated with CRAE. In the same model, there were significant interactions between concurrent and previous systolic BP (0.11; P = .003) and between concurrent and previous body mass index (0.12; P = .04). Use of calcium channel blockers at both the concurrent and past examination (vs neither examination, 1.59; P = .01), but not other classes of antihypertensive drugs, was associated with CRAE.
CONCLUSIONS: Retinal arteriolar diameter is independently associated with past and current systolic BP, calcium channel blocker use, smoking status, body mass index, and heavy drinking during 5-year intervals. The relationships with CRAE are stronger for concurrent than for past measures of these variables.
Ronald Klein; Chelsea E Myers; Michael D Knudtson; Kristine E Lee; Ronald Gangnon; Tien Y Wong; Barbara E K Klein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  130     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-15     Completed Date:  2012-10-30     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1019-27     Citation Subset:  AIM; IM    
Department of Ophthalmology & Visual Sciences, University of Wisconsin School of Medicine and Public Health, 610 N Walnut St, 417 WARF, Madison, WI 53726, USA.
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MeSH Terms
Aged, 80 and over
Alcohol Drinking / epidemiology*
Antihypertensive Agents / therapeutic use*
Arterioles / pathology
Blood Pressure / physiology*
Body Mass Index
Calcium Channel Blockers / therapeutic use
Middle Aged
Retinal Artery / pathology*
Risk Factors
Smoking / epidemiology*
Wisconsin / epidemiology
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers

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