Document Detail

Relationship of blood pressure and obesity with inflammatory cytokines among African Americans.
MedLine Citation:
PMID:  21558084     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Hypertension and obesity are major public health issues. Both conditions are highly prevalent among African Americans and contribute to the increased burden of cardiovascular disease in this group. Inflammation is considered to be an underlying process in both conditions. The authors sought to determine if there is an interaction between high blood pressure (HBP) and obesity that is associated with markedly elevated plasma levels of proinflammatory cytokines in African American adults.
METHODS: This study examined 484 African Americans, aged 18-45 years, including people with and without obesity, and also with and without HBP. People known to have diabetes were not enrolled. Plasma levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), plasminogen activator inhibitor 1, tumor necrosis factor alpha (TNF-α), and adiponectin were measured. Participants also underwent an oral glucose tolerance test and measurement of blood pressure and body mass index (BMI).
RESULTS: There was no statistically significant interaction between obesity and HBP on plasma levels of adiponectin or the inflammatory cytokines. When both conditions were present, HBP and obesity had additive associations with the expected geometric mean ratios for IL-6 (1.44, 95% CI 1.18 to 1.75), TNF-α (1.31, 95% CI 1.11 to 1.53), hsCRP (2.55, 95% CI 1.99 to 3.26) and negative association with adiponectin (0.61, 95% CI 0.52 to 0.71). Compared with HBP, obesity had the predominant association with cytokine levels. An increase in cytokine plasma levels was detectable when BMI exceeded 25 kg/m2.
CONCLUSIONS: Biomarkers of inflammation in African Americans are strongly associated with BMI. A modest additive effect is found with HBP. Interventions to reduce obesity-related inflammation may impact cardiovascular disease outcomes.
Stephanie DeLoach; Yonghong Huan; Scott W Keith; Maria P Martinez Cantarin; Bonita Falkner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-09
Journal Detail:
Title:  Therapeutic advances in cardiovascular disease     Volume:  5     ISSN:  1753-9455     ISO Abbreviation:  Ther Adv Cardiovasc Dis     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-09-30     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  101316343     Medline TA:  Ther Adv Cardiovasc Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  149-57     Citation Subset:  IM    
Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.
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MeSH Terms
Adiponectin / blood
African Americans / statistics & numerical data*
Analysis of Variance
Blood Glucose / analysis
Blood Pressure*
Body Mass Index
C-Reactive Protein / analysis
Cytokines / blood*
Hypertension / ethnology*,  immunology,  physiopathology
Inflammation Mediators / blood*
Insulin / blood
Interleukin-6 / blood
Linear Models
Obesity / ethnology*,  immunology,  physiopathology
Philadelphia / epidemiology
Plasminogen Activator Inhibitor 1 / blood
Tumor Necrosis Factor-alpha / blood
Young Adult
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Blood Glucose; 0/Cytokines; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Insulin; 0/Interleukin-6; 0/Plasminogen Activator Inhibitor 1; 0/SERPINE1 protein, human; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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