| Relationship of blood pressure and obesity with inflammatory cytokines among African Americans. | |
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MedLine Citation:
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PMID: 21558084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Hypertension and obesity are major public health issues. Both conditions are highly prevalent among African Americans and contribute to the increased burden of cardiovascular disease in this group. Inflammation is considered to be an underlying process in both conditions. The authors sought to determine if there is an interaction between high blood pressure (HBP) and obesity that is associated with markedly elevated plasma levels of proinflammatory cytokines in African American adults. METHODS: This study examined 484 African Americans, aged 18-45 years, including people with and without obesity, and also with and without HBP. People known to have diabetes were not enrolled. Plasma levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), plasminogen activator inhibitor 1, tumor necrosis factor alpha (TNF-α), and adiponectin were measured. Participants also underwent an oral glucose tolerance test and measurement of blood pressure and body mass index (BMI). RESULTS: There was no statistically significant interaction between obesity and HBP on plasma levels of adiponectin or the inflammatory cytokines. When both conditions were present, HBP and obesity had additive associations with the expected geometric mean ratios for IL-6 (1.44, 95% CI 1.18 to 1.75), TNF-α (1.31, 95% CI 1.11 to 1.53), hsCRP (2.55, 95% CI 1.99 to 3.26) and negative association with adiponectin (0.61, 95% CI 0.52 to 0.71). Compared with HBP, obesity had the predominant association with cytokine levels. An increase in cytokine plasma levels was detectable when BMI exceeded 25 kg/m2. CONCLUSIONS: Biomarkers of inflammation in African Americans are strongly associated with BMI. A modest additive effect is found with HBP. Interventions to reduce obesity-related inflammation may impact cardiovascular disease outcomes. |
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Authors:
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Stephanie DeLoach; Yonghong Huan; Scott W Keith; Maria P Martinez Cantarin; Bonita Falkner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-05-09 |
Journal Detail:
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Title: Therapeutic advances in cardiovascular disease Volume: 5 ISSN: 1753-9455 ISO Abbreviation: Ther Adv Cardiovasc Dis Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-09 Completed Date: 2011-09-30 Revised Date: 2012-04-09 |
Medline Journal Info:
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Nlm Unique ID: 101316343 Medline TA: Ther Adv Cardiovasc Dis Country: England |
Other Details:
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Languages: eng Pagination: 149-57 Citation Subset: IM |
Affiliation:
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Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adolescent Adult African Americans / statistics & numerical data* Analysis of Variance Blood Glucose / analysis Blood Pressure* Body Mass Index C-Reactive Protein / analysis Cytokines / blood* Female Humans Hypertension / ethnology*, immunology, physiopathology Inflammation Mediators / blood* Insulin / blood Interleukin-6 / blood Linear Models Male Obesity / ethnology*, immunology, physiopathology Philadelphia / epidemiology Plasminogen Activator Inhibitor 1 / blood Tumor Necrosis Factor-alpha / blood Up-Regulation Young Adult |
| Chemical | |
Reg. No./Substance:
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0/ADIPOQ protein, human; 0/Adiponectin; 0/Blood Glucose; 0/Cytokines; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Insulin; 0/Interleukin-6; 0/Plasminogen Activator Inhibitor 1; 0/SERPINE1 protein, human; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein |
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