| Relationship of blood flow and metabolism to acoustic processing centers of the dolphin brain. | |
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MedLine Citation:
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PMID: 20815480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Odontocete brain tissues associated with auditory processing are hypertrophied and modified relative to their terrestrial counterparts. The relationship between the functional demand on these tissues and metabolic substrate requirements is unknown. Using positron emission tomography (PET), relative cerebral blood flow was measured in a bottlenose dolphin. Approximately 60 mCi (13)NH(3) was administered to the dolphin via a catheter inserted into the hepatic vein and threaded proximate to the vena cava. Radiolabel initially appeared as distributed focal points in the cerebellum. Increasing scan time resulted in an increase in the number of focal regions and in the diffusivity of label activity throughout the brain. The time course and spatial distribution of radiolabel was consistent with a cerebral blood supply dominated by the spinal meningeal arteries. Blood flow was predominantly observed in the cerebellum and neocortex, particularly the auditory and visual cortex. Differential brain glucose uptake, previously measured in a separate dolphin, showed good agreement with the differential supply of blood to brain tissues. Rates of blood supply and glucose uptake in the auditory cortex, inferior colliculus, and cerebellum are consistent with a high metabolic demand of tissues which are important to the integration of auditory and other sensory inputs. |
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Authors:
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Dorian S Houser; Patrick W Moore; Shawn Johnson; Betsy Lutmerding; Brian Branstetter; Sam H Ridgway; Jennifer Trickey; James J Finneran; Eric Jensen; Carl Hoh |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of the Acoustical Society of America Volume: 128 ISSN: 1520-8524 ISO Abbreviation: J. Acoust. Soc. Am. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2011-01-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503051 Medline TA: J Acoust Soc Am Country: United States |
Other Details:
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Languages: eng Pagination: 1460-6 Citation Subset: IM |
Affiliation:
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National Marine Mammal Foundation, 2240 Shelter Island Drive, San Diego, California 92106, USA. dorian.houser@nmmfoundation.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Auditory Cortex / blood supply, metabolism Auditory Perception* Bottle-Nosed Dolphin / physiology* Brain / blood supply*, metabolism*, radionuclide imaging Brain Mapping / methods Cerebellum / blood supply, metabolism Cerebrovascular Circulation* Energy Metabolism* Glucose / metabolism* Male Nitrogen Radioisotopes / administration & dosage Positron-Emission Tomography Quaternary Ammonium Compounds / administration & dosage Time Factors Visual Cortex / blood supply, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Nitrogen Radioisotopes; 0/Quaternary Ammonium Compounds; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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