| Relationship between the weight of parathyroid glands and their secretion of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism. | |
MedLine Citation:
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PMID: 18937722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Secondary hyperparathyroidism is one of the common and important abnormalities of mineral metabolism in hemodialysis patients. In this study we investigated the relationship between the weight of individual parathyroid glands (PTG) and their secretion of parathyroid hormone (PTH). Sixty-four PTGs in 16 patients undergoing parathyroidectomy (PTx) at our hospital were included in this study. Patients' ages ranged from 34 to 68 years (60.3 +/- 6.6 years). They were undergoing maintenance dialysis therapy for 81-256 months (175.3 +/- 56.0 months). The cause of end-stage renal failure was chronic glomerulonephritis in all patients. We measured whole PTH (wPTH) levels before PTx and 15 min after the resection of each individual gland (Delta whole PTH). A positive correlation was found between the weight of individual gland and ultrasonography (US) size of individual PTG (r = 0.91, P < 0.001, N = 53). A positive correlation was found between the total mass of the gland and the total volume of PTG on US (r = 0.896, P < 0.001, N = 16). A positive correlation was found between the mass of each individual gland and Delta whole PTH (r = 0.625, P < 0.001, N = 64); however, massive PTGs did not secrete more whole PTH per unit mass (0.01 g). Determination of the volume of PTGs by US is a good indicator of their weight. Larger PTGs secrete more whole PTH per gland, whereas these PTGs did not have the ability to secrete more PTH per unit volume. |
Authors:
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Takatoshi Kakuta; Reika Tanaka; Genta Kanai; Yoshiyasu Miyamoto; Miho Inagaki; Hajime Suzuki; Masafumi Fukagawa; Akira Saito |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 12 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-21 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
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Languages: eng Pagination: 385-90 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan. kakuta@is.icc.u-tokai.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cohort Studies Female Follow-Up Studies Humans Hyperparathyroidism, Secondary / etiology*, physiopathology, surgery* Kidney Failure, Chronic / diagnosis, mortality, therapy* Male Middle Aged Organ Size Parathyroid Glands / secretion*, ultrasonography Parathyroid Hormone / blood* Parathyroidectomy / methods Predictive Value of Tests Probability Renal Dialysis / adverse effects*, methods Risk Assessment Statistics, Nonparametric Survival Rate Treatment Outcome Ultrasonography, Doppler |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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