Document Detail


Relationship between the weight of parathyroid glands and their secretion of parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.
MedLine Citation:
PMID:  18937722     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Secondary hyperparathyroidism is one of the common and important abnormalities of mineral metabolism in hemodialysis patients. In this study we investigated the relationship between the weight of individual parathyroid glands (PTG) and their secretion of parathyroid hormone (PTH). Sixty-four PTGs in 16 patients undergoing parathyroidectomy (PTx) at our hospital were included in this study. Patients' ages ranged from 34 to 68 years (60.3 +/- 6.6 years). They were undergoing maintenance dialysis therapy for 81-256 months (175.3 +/- 56.0 months). The cause of end-stage renal failure was chronic glomerulonephritis in all patients. We measured whole PTH (wPTH) levels before PTx and 15 min after the resection of each individual gland (Delta whole PTH). A positive correlation was found between the weight of individual gland and ultrasonography (US) size of individual PTG (r = 0.91, P < 0.001, N = 53). A positive correlation was found between the total mass of the gland and the total volume of PTG on US (r = 0.896, P < 0.001, N = 16). A positive correlation was found between the mass of each individual gland and Delta whole PTH (r = 0.625, P < 0.001, N = 64); however, massive PTGs did not secrete more whole PTH per unit mass (0.01 g). Determination of the volume of PTGs by US is a good indicator of their weight. Larger PTGs secrete more whole PTH per gland, whereas these PTGs did not have the ability to secrete more PTH per unit volume.
Authors:
Takatoshi Kakuta; Reika Tanaka; Genta Kanai; Yoshiyasu Miyamoto; Miho Inagaki; Hajime Suzuki; Masafumi Fukagawa; Akira Saito
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy     Volume:  12     ISSN:  1744-9987     ISO Abbreviation:  Ther Apher Dial     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181252     Medline TA:  Ther Apher Dial     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  385-90     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Tokai University School of Medicine, Kanagawa, Japan. kakuta@is.icc.u-tokai.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cohort Studies
Female
Follow-Up Studies
Humans
Hyperparathyroidism, Secondary / etiology*,  physiopathology,  surgery*
Kidney Failure, Chronic / diagnosis,  mortality,  therapy*
Male
Middle Aged
Organ Size
Parathyroid Glands / secretion*,  ultrasonography
Parathyroid Hormone / blood*
Parathyroidectomy / methods
Predictive Value of Tests
Probability
Renal Dialysis / adverse effects*,  methods
Risk Assessment
Statistics, Nonparametric
Survival Rate
Treatment Outcome
Ultrasonography, Doppler
Chemical
Reg. No./Substance:
0/Parathyroid Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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