Document Detail

Relationship between visceral fat accumulation and anti-lipolytic action of insulin in patients with type 2 diabetes mellitus.
MedLine Citation:
PMID:  12402978     Owner:  NLM     Status:  MEDLINE    
Insulin resistance is closely related to developing type 2 diabetes mellitus. Visceral fat accumulation is associated with insulin resistance, which affects the free fatty acid (FFA) metabolism. We investigated the interactions among visceral fat accumulation, FFA metabolism and insulin resistance in 20 patients with type 2 diabetes mellitus, including 11 obese and 9 non-obese subjects. Body fat distribution was estimated by measuring the areas of both subcutaneous and visceral fat mass on abdominal computed tomography at the umbilical level. Glucose infusion rate (GIR) and plasma FFA responses to insulin were determined as an index of insulin resistance and anti-lipolytic action, respectively, in a euglycemic hyperinsulinemic clamp study. There was an inverse correlation between GIR and insulin-induced decrease in plasma FFA in all diabetic patients (r = -0.652, P < 0.01). Visceral fat mass area was well correlated with GIR (r = -0.583, P < 0.01) and insulin-induced decrease in plasma FFA (r = 0.724, P < 0.001), whereas subcutaneous fat mass area was not correlated either with GIR or plasma FFA decrease. These findings suggest that visceral fat accumulation results in increasing the resistance against the anti-lipolytic action of insulin, and that FFA metabolism is closely related with glucose utilization in patients with type 2 diabetes mellitus.
Soichi Kurioka; Yoshio Murakami; Masateru Nishiki; Motoi Sohmiya; Kunio Koshimura; Yuzuru Kato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine journal     Volume:  49     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-29     Completed Date:  2003-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  459-64     Citation Subset:  IM    
Department of Medicine, Shimane Medical University, Izumo, Japan.
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MeSH Terms
Adipose Tissue / pathology*
Diabetes Mellitus, Type 2 / blood,  drug therapy*,  pathology*
Fatty Acids, Nonesterified / blood
Glucose Clamp Technique
Hypoglycemic Agents / therapeutic use*
Insulin / therapeutic use*
Lipolysis / drug effects*
Middle Aged
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Hypoglycemic Agents; 11061-68-0/Insulin

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