Document Detail

Relationship between the ventromedullary clonidine-sensitive area and the posterior hypothalamus.
MedLine Citation:
PMID:  330175     Owner:  NLM     Status:  MEDLINE    
The connections between the areas 'S' which have been previously described as the ventromedullary sites of the action of clonidine and the posterior hypothalamus have been investigated. Superficial electrocoagulation of the left area 'S' suppresses the pressor response to electrical stimulation of the homolateral part of the posterior hypothalamus. Although such medullary lesions cause a significant reduction of the mean arterial pressure, the contralateral hypothalamic stimulation can still increase blood pressure. Clonidine it self applied topically (8 micrograms/kg) to the ventral face of the brain stem decreases the blood pressure response to liminal hypothalamic stimulation. It is concluded that efferent pathways, which are involved in vasomotor regulation, originate in the posterior hypothalamus and run through the ventrolateral part of the brain stem. The mechanism of the blocking effect of clonidine on these pathways is discussed.
R Bloch; J Feldman; P Bousquet; J Schwartz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  45     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-31     Completed Date:  1977-10-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Clonidine / pharmacology*
Electric Stimulation
Hypothalamus / physiology*
Hypothalamus, Posterior / physiology*
Medulla Oblongata / drug effects,  physiology*
Stereotaxic Techniques
Reg. No./Substance:

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