Document Detail

Relationship between ventricular expression of atrial natriuretic polypeptide gene and hemodynamic parameter in old myocardial infarction.
MedLine Citation:
PMID:  2473339     Owner:  NLM     Status:  MEDLINE    
Using Northern blot analysis and radioimmunoassay, we measured atrial natriuretic polypeptide (ANP) messenger RNA and ANP levels in the ventricle in patients with old myocardial infarction and investigated the relationship between ventricular ANP synthesis and hemodynamic parameters. Levels of ANP messenger RNA and ANP were markedly increased in the left ventricular aneurysm, and a positive correlation was observed between the ANP level in the left ventricular aneurysm and pulmonary capillary wedge pressure (r = 0.85, p less than 0.05). These findings indicate that ANP synthesis in the ventricle is increased in accordance with the severity of congestive heart failure.
Y Saito; K Nakao; H Arai; K Nishimura; G Takemura; H Fujiwara; A Sugawara; T Yamada; H Itoh; M Makoyama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  13 Suppl 6     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S1-4     Citation Subset:  IM    
Department of Medicine, Kyoto University School of Medicine, Japan.
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MeSH Terms
Atrial Natriuretic Factor / biosynthesis*,  genetics
Blotting, Northern
Gene Expression Regulation
Heart Aneurysm / physiopathology
Heart Ventricles
Middle Aged
Myocardial Infarction / genetics,  metabolism*,  physiopathology
Myocardium / metabolism*
RNA, Messenger / genetics
Reg. No./Substance:
0/RNA, Messenger; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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