| Relationship between ventricular expression of atrial natriuretic polypeptide gene and hemodynamic parameter in old myocardial infarction. | |
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MedLine Citation:
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PMID: 2473339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using Northern blot analysis and radioimmunoassay, we measured atrial natriuretic polypeptide (ANP) messenger RNA and ANP levels in the ventricle in patients with old myocardial infarction and investigated the relationship between ventricular ANP synthesis and hemodynamic parameters. Levels of ANP messenger RNA and ANP were markedly increased in the left ventricular aneurysm, and a positive correlation was observed between the ANP level in the left ventricular aneurysm and pulmonary capillary wedge pressure (r = 0.85, p less than 0.05). These findings indicate that ANP synthesis in the ventricle is increased in accordance with the severity of congestive heart failure. |
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Authors:
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Y Saito; K Nakao; H Arai; K Nishimura; G Takemura; H Fujiwara; A Sugawara; T Yamada; H Itoh; M Makoyama |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 13 Suppl 6 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-08-25 Completed Date: 1989-08-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S1-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, Kyoto University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrial Natriuretic Factor / biosynthesis*, genetics Blotting, Northern Female Gene Expression Regulation Heart Aneurysm / physiopathology Heart Ventricles Hemodynamics* Humans Male Middle Aged Myocardial Infarction / genetics, metabolism*, physiopathology Myocardium / metabolism* RNA, Messenger / genetics Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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