Document Detail

Relationship between urea clearance and ionic dialysance determined using a single-step conductivity profile.
MedLine Citation:
PMID:  16221245     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: On-line determination of ionic dialysance (ID) has been used to measure the clearance of small solutes like urea. However, attempts to determine the in vivo relationship between ID and urea clearance have led to discordant findings. The aim of this study was to determine the relationship between the mean values of repeated instantaneous determinations of ID throughout a dialysis session ((m)ID), obtained using a single-step inlet dialysate conductivity profile, and the mean values of urea clearance corrected for access recirculation (K(eu1)), total recirculation (access plus cardiopulmonary recirculation, K(eu2)), and the entire postdialysis urea rebound (K(wb)). METHODS: Eighty-two anuric patients on chronic thrice-weekly hemodialysis were studied using an Integra machine equipped with the Diascan module for the automatic determination of ID. The mean values of repeated ID measurements made at 30-minute intervals were compared with K(eu1) (available for only 31 patients), K(eu2), and K(wb). RESULTS: The results in all 82 patients were: (m)ID = 176 +/- 23 mL/min; K(eu2) = 181 +/- 25 mL/min; K(wb) = 159 +/- 22 mL/min. The mean (m)ID/K(wb) and (m)ID/K(eu2) ratios were, respectively, 1.11 +/- 0.06 and 0.98 +/- 0.06. The results in the 31 patients for whom K(eu1) values were available were: (m)ID = 179 +/- 24 mL/min and K(eu1) = 200 +/- 27 mL/min; the mean (m)ID/K(eu1) ratio was 0.90 +/- 0.05. CONCLUSION: The mean value of repeated ID determinations obtained using a single-step conductivity profile underestimates urea clearance corrected for access recirculation, and may be considered an adequate estimate of urea clearance corrected for total recirculation.
Salvatore Di Filippo; Pietro Pozzoni; Celestina Manzoni; Simeone Andrulli; Giuseppe Pontoriero; Francesco Locatelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  68     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-13     Completed Date:  2006-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2389-95     Citation Subset:  IM    
Department of Nephrology and Dialysis, A. Manzoni Hospital, Lecco, Italy.
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MeSH Terms
Anuria / metabolism,  therapy
Kidney Failure, Chronic / metabolism*,  therapy*
Models, Biological*
Regression Analysis
Renal Dialysis / instrumentation,  methods*
Urea / metabolism*
Reg. No./Substance:

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