| Relationship between upregulation of CD40 system and restenosis in patients after percutaneous coronary intervention. | |
| | |
MedLine Citation:
|
PMID: 17302995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To investigate whether the increasing CD40-CD40 ligand system is related to restenosis in patients after percutaneous coronary intervention (PCI). METHODS: Twenty normal controls and 120 patients with PCI were investigated. The expression of CD40 and the CD40 ligand (CD40L) on platelets was analyzed by indirectimmunofluorescence flow cytometry. The serum level of soluble CD40L (sCD40L) and C-reactive protein (CRP) was determined by commercially available enzyme linked immunosorbent assay. Restenosis was observed in 120 patients within a 6 month follow-up period after PCI surgery. RESULTS: Restenosis occurred in 29 patients (24.2%). Patients who developed restenosis showed higher levels of CD40-CD40L system compared with non-restenotic patients before PCI. All restenotic patients showed a significant increase in CD40 [66.9 +/-4.8, mean fluorescence intensity (MFI)] and CD40L (14.9 +/-1.8, MFI) co-expression on platelets as well as sCD40L (13.7 +/-1.7 ng/mL) compared with non-restenotic patients and controls during the 6 month follow-up period (P<0.01). Elevated sCD40L and CD40L were significantly correlated with the serum level of CRP after percutaneous transluminal coronary angioplasty and with lumen loss during the 6 month followup period. CONCLUSION: The level of CD40L was associated with late restenosis after PCI indicating that restenosis is an inflammatory disorder. |
| | |
Authors:
|
Jin-Chuan Yan; Shu Ding; Yi Liang; Gen-Shan Ma; Jian Zhu; Yi Feng; Dan Luo |
Related Documents
:
|
18296835 - Multiple yellow plaques assessed by angioscopy with quantitative colorimetry in patient... 11481565 - Prediction of severe coronary artery disease and long-term outcome in patients undergoi... 16485055 - Noninvasive detection of silent coronary artery disease in patients with essential hype... 20561855 - Plasma circulatory markers in male and female patients with coronary artery disease. 23274815 - Use of portable x-ray fluorescence (pxrf) in vivo as an alternative technique for the a... 11126275 - Prothrombin gene g20210a mutation and elevated anticardiolipin antibodies in a patient ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta pharmacologica Sinica Volume: 28 ISSN: 1671-4083 ISO Abbreviation: Acta Pharmacol. Sin. Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-16 Completed Date: 2009-04-30 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100956087 Medline TA: Acta Pharmacol Sin Country: China |
Other Details:
|
Languages: eng Pagination: 339-43 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. yanjinchuan@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Transluminal, Percutaneous Coronary Animals Antigens, CD40 / biosynthesis* Blood Platelets / metabolism C-Reactive Protein / metabolism CD40 Ligand / biosynthesis Follow-Up Studies Graft Occlusion, Vascular / genetics*, pathology* Humans Mice Up-Regulation |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD40; 147205-72-9/CD40 Ligand; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus.
Next Document: Ouabain induces cardiac remodeling in rats independent of blood pressure.