Document Detail


[Relationship between tumor necrosis factor beta gene polymorphism and acute respiratory distress syndrome after operation for esophageal carcinoma].
MedLine Citation:
PMID:  19958618     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Background and Objective: A single nucleotide polymorphism of the tumor necrosis factor beta (TNFbeta) gene affected the level of tumor necrosis factor beta and was associated with prognosis of acute respiratory distress syndrome (ARDS). This study was to investigate the association between the TNFbeta and ARDS after operation for esophageal carcinoma. Methods: Thirty-four patients with and 116 patients without ARDS after radical resection for thoracotomic esophageal carcinoma were recruited in the Fourth Hospital of Hebei Medical University from January 2005 to June 2007. Peripheral blood samples were collected and DNA extracted. TNFbeta genotype was determined by restriction fragment length polymorphism (RPLF). Results: There was no significant difference between the two groups in the TNFbeta genotype and allele frequency (P>0.05). The time of mechanical ventilation was shorter and that of staying in the intesive care unit was longer for ARDS patients with the 1/2 genotype in the TNFbeta than for those with other genotypes (both P<0.05). The frequency of the 1/1 genotype and 1 allele in the TNFbeta was significantly higher in the group of surviving patients with ARDS than in the group of death patients. The odd ratios for mortality of two groups were 16.5 and 11.2, respectively. Conclusions: TNFbeta did not appear to be a contributing factor influencing the morbidity of the patients with ARDS after operation for esophageal carcinoma, however, it might affect the development and prognosis of ARDS.
Authors:
Li-Xia Liu; Xue-Jian You; Yu-Xiang Zhang; Chai Zhao; Lei Chen; Zhen-Jie Hu
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Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Ai zheng = Aizheng = Chinese journal of cancer     Volume:  28     ISSN:  1000-467X     ISO Abbreviation:  Ai Zheng     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9424852     Medline TA:  Ai Zheng     Country:  China    
Other Details:
Languages:  chi     Pagination:  1255-9     Citation Subset:  IM    
Affiliation:
Intensive Care Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050011, P. R. China.
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