Document Detail

Relationship between tone burst discharge pattern and spontaneous firing rate of auditory nerve fibres in the guinea pig.
MedLine Citation:
PMID:  1774213     Owner:  NLM     Status:  MEDLINE    
A detailed investigation was carried out of the response of single auditory nerve fibres in the guinea pig to tone bursts. Comparisons were made between the shapes of peri-stimulus-time histograms (PSTHs) of low and high characteristic frequency (CF) fibres grouped according to their spontaneous firing rates (SR). Both low and high CF fibres of high spontaneous rate (greater than 18 spikes/s) exhibited marked rapid adaptation in their PSTH's which became most pronounced at high stimulus intensities. The ratio of onset-to-adapted firing estimated from PSTH data in these fibres increased monotonically as a function of adapted firing rate. The behaviour of fibres with the lowest spontaneous rates (less than 0.5 spikes/s) was markedly different, particularly in fibres from low CF regions. In general, these low-SR fibres showed slower adaptation than high-SR fibres, and a less pronounced onset peak. This was most striking in low CF fibres. Furthermore, the ratio of onset-to-adapted firing rate tended to decrease with increasing stimulus intensity in both low and high CF fibres with low spontaneous firing rates. Low-SR fibres also showed the highest maximum discharge rates to tone burst stimuli. Fibres with medium spontaneous rates between 0.5 and 18 spikes/s displayed intermediate characteristics in their PSTH's. Recent data in the chinchilla (Relkin and Doucet, 1991), suggest that these differences may arise in part from differences in inter-stimulus recovery processes in the different spontaneous rate groups.
M Müller; D Robertson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hearing research     Volume:  57     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-04     Completed Date:  1992-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Department of Physiology, University of Western Australia, Nedlands.
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MeSH Terms
Acoustic Stimulation
Action Potentials
Evoked Potentials, Auditory
Guinea Pigs
Nerve Fibers / physiology
Vestibulocochlear Nerve / physiology*

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