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Relationship between tissue glycation measured by autofluorescence and pulse wave velocity in young and elderly non-diabetic populations.
MedLine Citation:
PMID:  22703717     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Advanced glycation end-products (AGEs) and pulse wave velocity (PWV) are pivotal indices of the processes of arterial ageing and damage accumulation. The aim of the present study was to investigate the impact of AGEs, as measured by a non-invasive skin autofluorescence method, on arterial stiffness, estimated by PWV, in two different age groups of non-diabetic subjects. METHODS AND PATIENTS: A total of 116 non-diabetic subjects were classified into two groups, with 55 subjects in the group aged <65years and 61 in the group aged ≥65years. AGEs were measured by skin autofluorescence while carotid-femoral PWV was assessed by tonometry. RESULTS: A significant (positive) association was observed between PWV and AGE skin autofluorescence in the younger age group (r=0.51; P<0.0001). However, this association was no longer significant after further adjustments for age and other factors on multiple regression analyses. In contrast, this correlation was not found in the elderly group (r=0.098; P=0.454). CONCLUSION: Younger non-diabetic subjects exhibit a different correlation profile between AGEs accumulated in skin and cfPWV as an index of arterial stiffness compared with elderly subjects. AGEs were significantly associated with cfPWV in younger individuals, but not in the elderly. A further study with a larger number of subjects is proposed to confirm the contribution of AGEs, the formation of which is manageable, as a determinant of arterial stiffness in younger subjects.
G Watfa; G Soulis; E Tartagni; A Kearney-Schwartz; C Borghi; P Salvi; A Benetos
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-13
Journal Detail:
Title:  Diabetes & metabolism     Volume:  -     ISSN:  1878-1780     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Department of Geriatrics, University Hospital of Nancy, 54500 Vandœuvre-lès-Nancy, France; Inserm, U961, Faculty of Medicine, Nancy, France; University of Nancy, Nancy, France; University Hospital of Nancy & Inserm Clinical Investigation Centre, CIC 9501, Nancy, France.
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