Document Detail


Relationship between systolic arterial pressure and heart mass in the rat.
MedLine Citation:
PMID:  8164346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study describes the relationship between left ventricular mass and systolic arterial pressure (SAP) in normotensive and hypertensive rats. The genetically hypertensive rats (SHR) were stratified according to their SAP values in to hypertensive (SHRH) and normotensive (SHRN) subgroups. Males and females of both subgroups exhibited biventricular hypertrophy and the left ventricular mass was not correlated with SAP values. An overall cardiac enlargement was also found in female rats of the normotensive WKY group. In DOCA-salt and 2K/1C hypertensive rats the left ventricular mass was correlated positively with SAP. These data suggest that SAP is not a factor in the development of left ventricular hypertrophy in the SHR strain, however, they also revealed a right ventricular mass increase in this strain with respect to the Wistar strain.
Authors:
A O Grassi de Gende
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese heart journal     Volume:  34     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-05-20     Completed Date:  1994-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  795-801     Citation Subset:  IM    
Affiliation:
Facultad de Ciencias Médicas, Departamento de Ciencias Biológicas, Universidad Nacional de La Plata, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure*
Female
Heart Ventricles / pathology
Hypertension / complications,  pathology*,  physiopathology*
Hypertrophy, Left Ventricular / etiology,  pathology
Hypertrophy, Right Ventricular / etiology,  pathology
Male
Myocardium / pathology*
Organ Size
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Systole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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