Document Detail


Relationship between sympathetic nerve activity and aortic wave reflection characteristics in postmenopausal women.
MedLine Citation:
PMID:  23531685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Aortic wave reflection characteristics, such as augmentation index, are positively related to muscle sympathetic nerve activity in young men. In young women, there is an inverse relationship. We investigated whether this inverse relationship persisted in postmenopausal women.
METHODS: Muscle sympathetic nerve activity (peroneal microneurography) and arterial pressure (brachial catheter) were measured in 16 postmenopausal women (mean [SEM] age, 60 [2] y). Aortic blood pressure and wave form characteristics were synthesized from radial arterial pressure waves (applanation tonometry). Specifically, augmentation index, wave reflection amplitude, and estimated wasted left ventricular energy were calculated. These data were compared with our previously published work from an identical protocol in 23 young women (mean [SEM] age, 25 [1] y).
RESULTS: Tonic sympathetic activity was higher in postmenopausal women than in young women (64 [3] vs 24 [4] bursts/100 heartbeats). All indices of aortic wave reflection were higher in postmenopausal women than in young women (P < 0.05). Baseline sympathetic activity was inversely related to augmentation index (r = -0.63, P < 0.05), augmented pressure (r = -0.62, P < 0.05), and wasted left ventricular energy (r = -0.61, P < 0.05) in young women. Conversely, baseline sympathetic activity was positively related to augmentation index (r = 0.63, P = 0.09), augmented pressure (r = 0.69, P < 0.05), and wasted left ventricular energy (r = 0.79, P < 0.05) in postmenopausal women.
CONCLUSIONS: High levels of sympathetic activity are associated with higher indices of aortic wave reflection in postmenopausal women. Consequently, postmenopausal women with high sympathetic activity may be more at risk for developing cardiovascular diseases or experiencing adverse cardiovascular system-related events.
Authors:
Emma C Hart; Nisha Charkoudian; Michael J Joyner; Jill N Barnes; Timothy B Curry; Darren P Casey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  20     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-29     Completed Date:  2014-03-17     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  967-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aorta / physiology*
Blood Flow Velocity / physiology
Blood Pressure / physiology*
Electric Stimulation / methods
Female
Humans
Middle Aged
Muscle, Skeletal / innervation*,  physiology*
Postmenopause*
Pulsatile Flow / physiology
Pulse Wave Analysis
Sympathetic Nervous System / physiology*
Women's Health
Grant Support
ID/Acronym/Agency:
1 UL1 RR024150/RR/NCRR NIH HHS; AG038067/AG/NIA NIH HHS; AR55819/AR/NIAMS NIH HHS; F32 AG038067/AG/NIA NIH HHS; F32 AR055819/AR/NIAMS NIH HHS; HL083947/HL/NHLBI NIH HHS; R01 HL083947/HL/NHLBI NIH HHS; UL1 TR000135/TR/NCATS NIH HHS
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