Document Detail

Relationship between surface facial dimensions and upper airway structures in obstructive sleep apnea.
MedLine Citation:
PMID:  20857873     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: We hypothesized that the facial phenotype is closely linked to upper airway anatomy. The aim of this study was to investigate the relationship between surface facial dimensions and upper airway structures using magnetic resonance imaging (MRI) in subjects with obstructive sleep apnea (OSA).
DESIGN: Cohort study.
SETTING: Sleep investigation unit.
PATIENTS: Sixty-nine patients (apnea-hypopnea index > or = 10/h) underwent MRI as part of a study of upper airway anatomy in oral appliance therapy.
INTERVENTIONS: Measurements of a range of surface facial dimensions and upper airway soft tissue volumes were performed on the MR images using image-analysis software. Pearson correlation analyses were performed.
MEASUREMENTS AND RESULTS: Significant correlations were identified between a number of surface facial dimensions and neck circumference. Significant positive correlations were demonstrated between surface facial dimensions (including facial widths, facial heights, nose width, interocular and intercanthal widths) and upper airway structures. The strongest associations were between the tongue volume and the midface width (r = 0.70, P < 0.001), and lower-face width (r = 0.60, P <0.001). Surface facial dimensions in combination were also strong determinants for tongue volume (r2 = 0.69). Correlations between surface soft tissue thickness and upper airway soft tissue volumes occurred at the level of the midface but not at the level of the lower face.
CONCLUSIONS: This study demonstrates that there is a relationship between surface facial dimensions and upper airway structures in subjects with OSA. These findings support the potential role of surface facial measurements in anatomic phenotyping for OSA.
Richard W W Lee; Kate Sutherland; Andrew S L Chan; Biao Zeng; Ronald R Grunstein; M Ali Darendeliler; Richard J Schwab; Peter A Cistulli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sleep     Volume:  33     ISSN:  0161-8105     ISO Abbreviation:  Sleep     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-12-23     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1249-54     Citation Subset:  IM    
Centre for Sleep Health and Research, Department of Respiratory Medicine, Royal North Shore Hospital St Leonards, NSW Australia.
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MeSH Terms
Body Weights and Measures
Cohort Studies
Face / pathology*
Magnetic Resonance Imaging
Middle Aged
Respiratory System / pathology*
Risk Factors
Sleep Apnea, Obstructive / etiology,  pathology*

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