Document Detail

Relationship between sulfate groups and biological activities of fucans.
MedLine Citation:
PMID:  11150589     Owner:  NLM     Status:  MEDLINE    
The anticoagulant and antiproliferative effects of low molecular weight fucans with different sulfate content were examined. The anticoagulant activity was determined by activated partial thromboplastin time and the antiproliferative one was achieved in vitro on CCL39 fibroblast cell line. The results showed that inhibitory effects of fucans on both coagulation and cell proliferation are dependent on their sulfation degree. Decreased sulfation diminishes the two activities not in the same manner: some low molecular weight fucan fractions with no anticoagulant activity retain their ability to inhibit cell growth.
F Haroun-Bouhedja; M Ellouali; C Sinquin; C Boisson-Vidal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis research     Volume:  100     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-06     Completed Date:  2001-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  453-9     Citation Subset:  IM    
Laboratoire de Recherches sur les Macromolecules (CNRS UMR7540, CNRS/IFREMER, URM2), Institut Galilée, Université Paris-Nord, Av. J.B. Clément 93430, Villetaneuse, France.
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MeSH Terms
Anticoagulants / chemistry*,  metabolism,  pharmacology*
Cell Line
Polysaccharides / chemistry*,  metabolism,  pharmacology*
Structure-Activity Relationship
Reg. No./Substance:
0/Anticoagulants; 0/Polysaccharides; 0/Sulfates; 3713-31-3/Fucose; 9072-19-9/fucoidan

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