Document Detail


Relationship between structural features and in vitro release of doxorubicin from biocompatible anionic microemulsion.
MedLine Citation:
PMID:  17614263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this work structural features of anionic microemulsions, containing the pharmaceutical biocompatible components soya phosphatidylcholine (SPC), eumulgin HRE 40 (EU) and sodium oleate (SO) as surfactant, cholesterol (CHO) as oil phase and aqueous buffer were studied. Microemulsions were formulated with and without the antitumor drug doxorubicin (DOX). The various microstructures characterized in the pseudo-ternary phase diagram were analyzed by polarized light microscopy, small-angle X-ray scattering (SAXS) and X-ray diffraction (XRD) as well as by their ability to incorporate and release DOX. The experimental results demonstrated a correlation between the composition, the structural features and drug delivery. It was found that at higher cholesterol contents, the crystallization of CHO polymorph phases changed the mobility of DOX molecules. Droplets were formed with short-range spatial correlation from a microemulsion (ME) with a low surfactant:oil ratio. More ordered structures with lamellar arrangements formed by the increasing of the CHO proportions in the formulation may be due to CHO crystallization. The in vitro release of DOX showed that the presence of a high content of crystalline CHO prolongs the release of DOX from ME. The retention of DOX in the internal oil phase of the ME may modulate the drug release for a prolonged time. These results clearly demonstrate the potential of ME as a drug-delivery system.
Authors:
T P Formariz; L A Chiavacci; V H V Sarmento; C V Santilli; E S Tabosa do Egito; A G Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-02
Journal Detail:
Title:  Colloids and surfaces. B, Biointerfaces     Volume:  60     ISSN:  0927-7765     ISO Abbreviation:  Colloids Surf B Biointerfaces     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-28     Completed Date:  2007-10-31     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9315133     Medline TA:  Colloids Surf B Biointerfaces     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  28-35     Citation Subset:  IM    
Affiliation:
Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas-UNESP, Rodovia Araraquara-Jaú km 01, 14801-902 Araraquara, SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Anions
Antibiotics, Antineoplastic / administration & dosage,  chemistry*,  pharmacokinetics*
Biocompatible Materials*
Doxorubicin / administration & dosage,  chemistry*,  pharmacokinetics*
Drug Delivery Systems
Emulsions*
Chemical
Reg. No./Substance:
0/Anions; 0/Antibiotics, Antineoplastic; 0/Biocompatible Materials; 0/Emulsions; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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