Document Detail


Relationship between size of injected microspheres and ultrasound imaging of heart by PLSR.
MedLine Citation:
PMID:  9358566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the enhancement in ultrasound signal (US) in heart, for diagnostic purposes, as a function of size and number of injected air-filled microspheres by multivariate statistical methods. METHODS: The US enhancement in left ventricle was measured after injection of 31 suspensions of air-filled albumin microspheres divided on and injected in six dogs. The relationship between the size of microspheres between 1-38 microns and the US enhancement was explored by Pearson's product moment correlation analysis, ordinary least-squares regression, principal component regression (PCR) and partial least-squares regression (PLS). RESULTS: Relative advanced algorithms such as PCR and PLS were required to achieve accurate in vivo/in vitro correlation. The most effective microsphere sizes contributing to US enhancement in left ventricle in dogs were estimated to be in the 7-15 microns range. CONCLUSIONS: In general, the effective in vivo sizes are dependent on the type of formulation due to the surprisingly large active in vivo sizes found for the tested concept. PCR and PLS are suitable methods for in vivo/in vitro correlation, especially for covariated and noisy data.
Authors:
K Dyrstad; P C Sontum
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  14     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-01-22     Completed Date:  1998-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1485-9     Citation Subset:  IM    
Affiliation:
Pharmaceutical Sciences, Research and Development Section, Nycomed Imaging AS, Oslo, Norway. Knut.dyrstad@nycomed.telemax.no
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MeSH Terms
Descriptor/Qualifier:
Albumins
Algorithms
Animals
Dogs
Echocardiography / methods*
Humans
Image Enhancement*
Microspheres
Multivariate Analysis
Particle Size
Regression Analysis
Chemical
Reg. No./Substance:
0/Albumins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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