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Relationship between sexual function and quality of life in obese persons seeking weight reduction.
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PMID:  23512339     Owner:  NLM     Status:  Publisher    
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OBJECTIVE: This study investigated sexual functioning in persons with obesity and seeking weight loss, and the associations of sexual functioning withrelevant demographic andclinical variables as well as quality of life. DESIGN AND METHODS: Participants were enrolled in a two-year randomizedclinical trial. Participants were obese and had at least two components of metabolic syndrome. Male and female sexual functioning was assessed by the International Index of Erectile Function (IIEF) and the Female Sexual Function Index (FSFI) respectively. RESULTS: The rate of female sexual dysfunction was 29%. The rate of erectile dysfunction (ED) was 45%. Of the characteristics considered, FSD was associated with age (p=0.002). ED was significantly associated with age and physical functioning (both p <0.01). CONCLUSIONS: A large minority of patients with obesity reported sexual dysfunction. The occurrence of sexual dysfunction was associated with age, but, surprisingly, not weight-related comorbidities. This may be the result of the nature of the study sample or the methods used to administer the questionnaires that assessed sexual functioning.
Authors:
Reneé H Moore; David B Sarwer; Jeffrey A Lavenberg; Ilana B Lane; Joanna L Perez; Sheri Volger; Thomas A Wadden
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-20
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Mar 
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Created Date:  2013-3-20     Completed Date:  -     Revised Date:  -    
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Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
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Languages:  ENG     Pagination:  -     Citation Subset:  -    
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Copyright © 2013 The Obesity Society.
Affiliation:
Department of Psychiatry, Center for Weight and Eating Disorders, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Biostatistics and Epidemiology, PerelmanSchool of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Statistics, North CarolinaStateUniversity, Raleigh, NC. rhmoore@ncsu.edu.
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Journal Information
Journal ID (nlm-journal-id): 101264860
Journal ID (pubmed-jr-id): 32902
Journal ID (nlm-ta): Obesity (Silver Spring)
Journal ID (iso-abbrev): Obesity (Silver Spring)
ISSN: 1930-7381
ISSN: 1930-739X
Article Information
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nihms-submitted publication date: Day: 25 Month: 3 Year: 2013
Electronic publication date: Day: 31 Month: 5 Year: 2013
Print publication date: Month: 10 Year: 2013
pmc-release publication date: Day: 01 Month: 4 Year: 2014
Volume: 21 Issue: 10
First Page: 1966 Last Page: 1974
PubMed Id: 23512339
ID: 3735672
DOI: 10.1002/oby.20398
ID: NIHMS436315

Relationship between Sexual Function and Quality of Life in Obese Persons Seeking Weight Reduction
Reneé H. Moore123
David B. Sarwer1
Jeffrey A. Lavenberg1
Ilana B. Lane1
Joanna L. Evans1
Sheri Volger1
Thomas A. Wadden1
1Department of Psychiatry, Center for Weight and Eating Disorders, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
2Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
3Department of Statistics, North Carolina State University, Raleigh, NC
Correspondence: Correspondence Author: Reneé H. Moore, Ph.D., NCSU, Department of Statistics, 2311 Stinson Drive, SAS Hall 5220, Raleigh, NC 27695-8203, Phone: 919-513-4859 Fax: 919-515-7591, rhmoore@ncsu.edu

INTRODUCTION

Many persons with obesity pursue weight loss for the anticipated health benefits. They also seek weight reduction because of its likely effects on quality of life. Numerous studies have suggested that obesity is associated with reduced health-related quality of life (HRQOL), particularly physical limitations, bodily pain, and fatigue (1-5). Other studies have focused more specifically on the deleterious impact of obesity on domains of weight-related quality of life, which encompasses the impact of obesity on health, but also work mobility, self-esteem, interpersonal relationships, body image, and sexual functioning (6).

Two reviews on the specific relationship between obesity and sexual functioning recently have been published (7,8). These reviews suggest that there is a moderate to strong association between obesity and sexual functioning for both genders, although women with obesity appear to report greater difficulties in sexual functioning than men. Yet, there is a strong association between obesity and erectile dysfunction (ED). Additionally, presence of metabolic syndrome appears to be significantly associated with female sexual dysfunction in women with type 2 diabetes (9). Across both genders, the severity of obesity, as well as the presence and treatment of obesity-related comorbidities (e.g. type 2 diabetes and hypertension) appears to be associated with greater impairments in sexual functioning (8).

Relatively few studies have specifically documented the rate of sexual dysfunction in both obese men and women specifically seeking weight reduction. For example, in the Look AHEAD study (10), almost 50% of men with obesity (mean BMI = 35.6 kg/m2) and type 2 diabetes reported mild to moderate degrees of erectile dysfunction, and 24.8% had complete erectile dysfunction. Kadioglu and colleagues (11) reported that 50% of women in an outpatient weight loss clinic reported a sexual dysfunction. Recently, Bond and colleagues (12) reported that 60% of women presenting for bariatric surgery (mean BMI = 45.0 kg/m2) reported a sexual dysfunction.

The present study sought to build upon this growing literature by investigating the rate of sexual dysfunction in a diverse sample of men and women with obesity who presented for weight loss treatment in the context of a research study being conducted in their primary care physicians’ offices. Furthermore, this study sought to identify whether demographic, clinical, and/or quality of life measurements were associated with female sexual dysfunction (FSD) or erectile dysfunction (ED). We hypothesized that participants who were older, heavier, and had a diagnosis of metabolic syndrome, hypertension, and/or diabetes would be more likely to experience sexual dysfunction. In addition, we hypothesized that participants who reported better quality of life would have decreased odds of meeting criteria for FSD or ED.


Methods
Study Design

This study utilized baseline data from a two-year randomized controlled clinical trial titled Practice-Based Opportunities for Weight Reduction at the University of Pennsylvania (POWER-UP), described elsewhere (13,14). Participants were 390 obese men and women who also had at least two components of the metabolic syndrome. The questionnaires used in these analyses were collected during the participants’ baseline visit, which took place between January 2008 and February 2009. The POWER-UP trial was approved by the University of Pennsylvania Institutional Review Board, and informed consent was received from all randomized participants.

Participants

Participants were recruited at six primary care practices which are owned by the University of Pennsylvania Health System. Eligible participants had to be 21 years of age or older, have a BMI of 30 to 50 kg/m2, be established patients in the practice, and have at least two of five criteria for the metabolic syndrome: elevated waist circumference; elevated triglycerides; reduced HDL cholesterol; elevated blood pressure; and elevated fasting glucose (15). Participants were screened over the course of two visits to determine that they met eligibility requirements. Only participants who were willing to complete the Female Sexual Function Index or the International Index of Erectile Function questionnaire at the randomization visit were included in this investigation. Participants were excluded if they were not in a committed relationship, as defined by being married or being in another committed relationship, including a domestic partnership or being engaged.

A flow chart of participants in this study is presented in Figure 1. A total of 390 questionnaires were handed out, and 229 were returned to the research staff, a response rate of 58.7%. Of those completed questionnaires, 64 were not included in this study because the participant was not in a committed relationship, yielding an effective response rate of 42.6% (36.0% of potential women and 67.1% of men).

Measures
Female Sexual Function Index (FSFI)

The FSFI is a 19-item scale which measures six domains of female sexual functioning: desire (range: 1.2-6); arousal (0-6); lubrication (0-6); orgasm (0-6); satisfaction (0.8-6); and pain (0-6). Higher scores on the questionnaire and subscales indicate better sexual function and less pain (16). Females who score ≤ 5 on the desire subscale are defined as having hypoactive sexual desire disorder (HSDD) (17). In addition, an overall total score that includes all domains and ranges from 2 to 36 can be obtained. A total FSFI score ≤ 26.55 is suggestive of female sexual dysfunction (FSD) (18). Though the desire subscale is used in the calculation for FSD, HSDD is not a subset of FSD or vice versa; a woman can be identified with a diagnosis of HSDD but not a diagnosis of FSD.

International Index of Erectile Function (IIEF)

The IIEF is a 15-item scale that assesses five domains of sexual functioning: erectile function (range: 0-30); orgasmic function (0-10); sexual desire (2-10); intercourse satisfaction (0-15); and overall satisfaction (2-10) (19,20). Lower scores indicate less satisfaction or more sexual dysfunction. Males who score < 26 on the IIEF erectile function subscale are defined as having erectile dysfunction (ED). Erectile dysfunction severity is classified as severe ED (6-10), moderate ED (11-21), mild ED (22-25), and no dysfunction (26-30).

Short Form Health Survey (SF-12)

The SF-12 is a 12 question, shortened version of the 36-item Short-Form Health Survey. Items are divided into two subscales: physical health and mental health (21). Lower scores indicate a lower health-related quality of life. Good evidence of reliability has been demonstrated between the SF-12 and the SF-36 in an obese population (22).

Impact of Weight on Quality of Life-Lite (IWQOL-Lite)

The IWQOL-Lite is a measure specifically designed for use with obese individuals (6). It contains 31 items, with each item beginning with the phrase “Because of my weight.” The measure examines five domains: physical function; self-esteem; sexual life; public distress; and work. Responses to the 31 items are combined to calculate a total score that ranges from 0 to 100; higher scores indicate a better quality of life (23).

EuroQol-5D-3L (EQ-5D)

The EQ-5D is a 5-question descriptive system that measures the following domains: mobility; self-care; usual activities; pain/discomfort; and anxiety/depression (24). Each domain has three levels: 1 = no problems; 2 = some problems; and 3 = severe problems. The answers from each domain are combined to create an index score that ranges from −0.11 to 1.0. Lower EQ-5D index scores indicate lower health status.

Patient Health Questionnaire-8 (PHQ-8)

The PHQ-8 is a shortened version of the Patient Health Questionnaire which was designed to help primary care physicians identify depression in their patients (25, 26). The measure has eight items on which participants rate the frequency with which each item is true for them. Scores on each item range from 0 (not at all) to 3 (nearly every day). A cumulative score ≥15 indicates that the patient may be clinically depressed.

Clinical characteristics

Metabolic syndrome was defined by having three of the following five conditions: systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg or on medication that lowers blood pressure; triglycerides ≥ 150 mg/dl or on medication that lowers triglycerides; waist circumference (≥ 40 inches for men, ≥ 35 inches for women); fasting blood sugar ≥ 100 mg/dl, had a pre-existing diagnosis of diabetes, or taking anti-diabetic medication; or high-density lipoprotein (HDL) (< 40 mg/dl for men, <50 mg/dl for women) (15). Diabetes mellitus was defined by current medication use or fasting glucose ≥ 126 mg/dL. Hypertension was defined by current medication use, systolic blood pressure ≥ 140 mmHg, or diastolic blood pressure ≥ 90 mmHg. Given associations observed in the sexual function literature (8), use of hypertension medication was also considered independently.

Socio-demographics, medication usage and medical history

All participants completed a brief questionnaire for socio-demographic characteristics. Medical history and current medication usage, including phosphodiesterase type 5 inhibitors and antihypertensive medications, were collected via self-report and confirmed by a study physician who reviewed the participants’ medical record.

Statistical Analysis

This analysis included 165 participants who, by self-report, were in a committed relationship (to account for regular access to a sexual partner) and completed at least 80% of the items on their gender-specific sexual functioning questionnaire. Participants’ baseline demographic and clinical characteristics were summarized. As is custom in the sexual functioning literature, all analyses were adjusted for age. Logistic regression was used to examine the associations between the binary diagnostic cut points for HSDD, FSD, and ED and the baseline and clinical characteristics. Mean with standard deviation or frequencies with percentages by HSDD, FSD, and ED status and the age adjusted p-value are reported. Ordinary least squares (OLS) regression models were fit to identify participant characteristics that were significantly associated with the subscales of FSFI and the IIEF, adjusted for age. The partial correlations of the demographic, clinical, or QOL characteristic and the age adjusted p-value are reported from each OLS model. All analyses were conducted using SAS, version 9.2. To adjust for multiple comparisons, an alpha level of p≤0.010 was utilized to identify statistically significant findings.


RESULTS
Participants’ Baseline Characteristics

Baseline descriptive characteristics of the 112 women and 53 men who met the criteria for this investigation are included in Table 1. Of the 225 participants not included in the study, 161 did not complete their gender-specific sexual functioning questionnaire, and 64 were not in a committed relationship. In comparison to the 64 participants excluded because they were not in a committed relationship, the 165 participants included in the present analysis had a significantly higher proportion of Caucasians (41% vs 71%, p<0.0001) and had a significantly higher household income (11% vs. 55% household income > $75,000; p<0.0001). Also, there was a lower proportion of Caucasians among included (n=165) as compared to the 161 participants who did not complete the questionnaire (71% of the included vs. 54%, p=0.002), as well as a higher proportion of persons with income greater than $75,000 (55% of the included vs. 28% of those who did not complete questionnaire, p<0.0001). There were no other significant differences between the 165 participants included in the study and those who did not complete the questionnaire or who were not in a committed relationship.

Female Sexual Functioning

Based on the FSFI total score, 29% of women met criteria for FSD. The mean baseline scores on the five FSFI subscales were quite similar, ranging from a mean (SD) of 4.0 (2.5) on the Pain subscale to a 5.1(0.8) on the Satisfaction subscale. Scores on the Lubrication, Orgasm, Arousal, and Desire subscales were 4.2 (2.1), 4.2 (2.0), 4.4 (1.7), and 4.7 (0.9), respectively. Combining the five subscales yielded a baseline mean FSFI total score of 27.2 (7.2), range 7.4-36.0. Based on scores on the Desire subscale, 65% of women met criteria for HSDD.

Male Sexual Functioning

Forty-five percent of men were identified as experiencing ED, based on the erectile function domain score of the IIEF. The mean (SD) of all the IIEF domains, Erectile Function, Orgasmic Function, Sexual Desire, Intercourse Satisfaction, and Overall Satisfaction domains were 22.5 (7.1), 8.5 (2.6), 7.2 (2.1), 9.7 (4.2), and 6.6 (2.5), respectively. Based on the erectile function domain score, five (9%) men reported Severe ED, 15 (28%) had Moderate ED, and four (8%) Mild ED. Twenty-nine men (55%) were free of ED.

Relationship between Sexual Function and Demographic/Clinical Characteristics

As illustrated in Table 2, women with FSD were significantly older than those without FSD (52.7 vs. 46.3 years; p=0.002). Women with HSDD had a significantly lower BMI than women without HSDD (37.7. vs. 40.0 kg/m2; p=0.0008). There were no other statistically significant associations with HSDD or FSD.

Regardless of whether a woman met diagnostic criteria for a specific disorder, age was significantly associated with the lubrication and pain domains, as well as the total score on the FSFI (Table 3). Those who reported use of hypertension medications had significantly poorer sexual functioning on the arousal and pain domains and total score of FSFI in comparison to those not utilizing hypertension medications (all p≤0.010). There were no other statistically significant associations of demographic or baseline clinical characteristics with FSFI domains and total score (Table 3).

Men with ED were significantly older (56 years) than those without ED (48) (p=0.005; Table 2). In men, and regardless of the presence of ED, there was a significant association between age and the erectile function and orgasmic function domains on the IIEF (all p≤0.010; Table 4). There were no other statistically significant associations of baseline demographic and clinical characteristics with the IIEF domain scores (Table 4).

Relationship of Sexual Functioning with Quality of Life and Depressive Symptoms

We also examined the relationship between the FSFI and IIEF and health- and weight-related quality of life (Table 2). Women with HSDD reported a better quality of life based on higher scores on the IWQOL-Lite total score than those who were not experiencing HSDD (69.0 vs. 60.8; p=0.004). Among all women, and as expected, the desire, lubrication, orgasm, and satisfaction domains of FSFI were positively correlated with the IWQOL-Lite total score (Table 3). In addition, the orgasm and pain domains of FSFI were positively correlated with the EQ-5D and the lubrication and pain domains were positively associated with mental health (SF-12). There were no other significant associations between the domains or total scores of the FSFI and QOL measures (Table 3).

In men, scores on SF-12’s Physical Health were significantly lower, indicating poorer QOL for men with ED (Table 2). Furthermore, all of the quality of life measures, including depression (PHQ-8), were positively correlated with at least one domain of the IIEF (Table 4).


DISCUSSION

In this sample, 29% of the women met the criteria for FSD and 45% of men had ED. Age (older) was the only variable of interest associated with FSD, which was surprising as we hypothesized additional variables would be significantly associated. In men, older age and poorer non-weight-related quality of life (physical functioning of SF-12) were both significantly related to ED.

Less than one third of the women in this study reported a sexual dysfunction based on all 6 domains of the FSFI (i.e. FSD). This is less than the rate found in at least one study of the general population (43%;16), a study of women in an outpatient weight loss clinic (50%;11) and women who presented for bariatric surgery (60%;12). One possible explanation for the differences is that our analysis was limited to women who reported they were married or in a committed relationship. This is in contrast, for example, with the study by Rosen and colleagues (16) who included married, divorced, and single women, some of whom may not have had regular access to a sexual partner. The lower rate of FSD in our study versus that of Bond and colleagues (12) may be associated with BMI differences. The mean BMI in the Bond et al. study was 46.1 ± 7.6 kg/m2, significantly larger than the mean BMI of women enrolled in this study (38.5 ± 4.5 kg/m2). Other studies have found that BMI is associated with impairments in health-related quality of life (1). It has also been associated with lower levels of weight-related quality of life, as assessed by the IWQOL-Lite, which includes a subscale that specifically assesses sexual functioning as related to body weight. In our study, FSD was not significantly associated with IWQOL-Lite. Another possible explanation for our differences in FSD rates could be related to the voluntary process for answering the IIEF or FSFI questionnaires in the larger POWER-UP study; it is possible that those who choose not to complete the questionnaire have higher rates of dysfunction but did not feel comfortable reporting it.

Although only 29% of women met criteria for FSD, which considers all 6 domains (including desire) of FSFI, 65% met criteria for HSDD, which is based only on the desire subscale. Despite the fact that only older age was significantly associated with FSD, BMI and weight-related quality of life were significantly associated with HSDD. As noted above, although the desire subscale of the FSFI is used in the calculation of FSD, the diagnostic cutoff for HSDD is not a subset of FSD or vice versa. Thus, differences are not surprising. In this study, the direction of the association between hypoactive sexual desire with BMI and weight-related quality of life is surprising; those with HSDD had lower BMI and better weight-related quality of life than those who did not meet criteria for HSDD. Sexual desire is unquestionably related to a range of cognitive, behavioral and physical factors. The present finding suggests that the relationship to body weight may be less strong than previously thought.

Less than half (45.2%) of men with obesity were found to suffer from some form of ED. This is substantially less than the 74.6% of men enrolled in the Look AHEAD trial (10), which investigated a similar weight loss intervention in men with type 2 diabetes. The differences in these results could be explained by the presence of diabetes in the Look AHEAD trial, or by differences in age. Men in the current study were younger than those in the Look AHEAD trial [52.0 (11.0) v. 60.5 (6.5)]. Within the current study, ED was associated with increasing age as well.

Intuitively, the difference between the present study and the Look AHEAD sample could be understood to be a function of diabetes status. Diabetes mellitus is widely acknowledged to be the single most common cause of erectile dysfunction. (7,8) Approximately 50% of men with diabetes develop erectile problems during the course of their disease and diabetes is present in approximately 25%-30% of all men presenting for sexual dysfunction treatment (27,28). However, in the present study, there was not a significant difference in the rate of ED in men with and without diabetes.

The relationship between sexual function and quality of life differed between males and females. None of the quality of life measures were associated with FSD; however, there were significant associations between poorer SF-12 Physical Functioning and ED. Further examination of the IWQOL-Lite subscales revealed that FSD was associated with the sexual life subscale (p=0.0005) but there was no association with any of the other subscales (physical function, self-esteem, public distress, work: all p>0.11). However for men, erectile dysfunction was associated with all IWQOL-Lite subscales (p<0.01), except for the self-esteem subscale (p=0.39). Further research is needed to tease out these differences between men and women in the association of sexual functioning and other quality of life measures. One speculation is the ubiquitous nature of advertisements for ED, which typically depict erectile functioning as an important aspect of quality of life. In the absence of similar medications for sexual functioning for women, it may be that women do not associate sexual functioning with quality of life in the same manner as men do.

The present study provides additional information on the sexual function of obese men and women who seek weight loss. However, the study also had a number of limitations. The greatest limitation may have been the differences between our sample and the larger POWER-UP trial. The manner in which we distributed and received the questionnaires may have contributed to this. POWER-UP participants were given the sexual functioning questionnaires before the onset of treatment and with a cover letter which stated: “The following questionnaire contains questions about your past physical and sexual experiences. Some of the questions are rather personal in nature and some of you may be somewhat uncomfortable answering them. While we would like you to complete all of the questions so that we are able to collect more information concerning this sensitive topic, if you find these questions too personal, please skip the next questionnaire.” Thus, completion was not required which likely had a detrimental impact on our response rate. In addition, participants returned the questionnaires directly to the research coordinator. Directly handing a questionnaire which includes very personal and sensitive information to another person also may have led some individuals not to participate. Taken together, these factors contributed to an effective response rate of 42.6% for the questionnaires, which is a great limitation of the present study.

In contrast, in the Look AHEAD study, sexual function was a primary outcome, participants received compensation specifically for completing the sexual function measures, and they returned them to the investigators in a sealed envelope. In addition, Look AHEAD investigators limited their sample to those that were sexually active within the last 6 months or in a committed relationship. All POWER-UP participants were asked to complete the questionnaire; however, only those in committed relationships were included in this analysis. Also, as discussed, all Look AHEAD participants had diabetes. These methodological differences may explain the different findings in this study and the Look AHEAD sexual functioning study.

The present study provides important and new information as well as some insight into the relationship between sexual functioning and quality of life in obese patients. The findings also suggest avenues for future research. Given the negative association between BMI and sexual functioning, studies should continue to investigate how weight change affects sexual function and, in turn, quality of life. Intuitively, weight loss would be anticipated to contribute to improvements in sexual functioning. However, changes in the comorbidities associated with obesity, including type 2 diabetes and hypertension, may moderate this relationship. Similarly, discontinuation of the medications that are used to treat those conditions may improve sexual functioning in men and women independent of body weight. The potential impact of these weight-related comorbidities, and the medications used to treat them, need to be thoughtfully evaluated in studies that will look at the impact of weight loss on sexual functioning.


Notes

FN1DISCLOSURE

Dr. David B. Sarwer discloses that he has consulting relationships with Allergan, Baronova, Enteromedics, Ethicon Endo-Surgery, and Galderma. Sheri Volger is currently affiliated with Pfizer. Dr. Thomas A. Wadden discloses that he has relationships with Novo Nordisk, Orexigen, Vivus, Nutrisystem, Guilford Press, and the Cardiometabolic Support Network.

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