Document Detail

Relationship between serum vitamin d status and clinical manifestations of primary hyperparathyroidism.
MedLine Citation:
PMID:  12173912     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare vitamin D status represented by serum 25-hydroxyvitamin D (25-OHD) levels in a group of patients with primary hyperparathyroidism, stratified by clinical manifestations. METHODS: We studied 22 patients (18 women and 4 men) with primary hyperparathyroidism--5 patients with severe osteitis fibrosa cystica, 10 symptomatic patients with active renal stone disease without overt bone disease, and 7 asymptomatic patients. Bone mineral density (BMD) measurements (T-scores) were done at the lumbar spine, femoral neck, and distal radius, and laboratory data for the three subgroups were analyzed. RESULTS: Although considerably younger than the asymptomatic group, patients with osteitis fibrosa had significantly lower mean serum 25-OHD levels (16.7 +/- 1.1 ng/mL versus 29.9 +/- 2.9 ng/mL; P = 0.003). Moreover, patients with osteitis fibrosa had significantly lower BMD in comparison with patients who had renal stone disease as well as asymptomatic patients for all sites measured. Serum parathyroid hormone levels were significantly higher in patients with osteitis fibrosa than in asymptomatic patients (1,352.8 +/- 297.2 pg/mL versus 145.0 +/- 43.7 pg/mL; P<0.02) as well as in comparison with patients who had renal stone disease (P<0.02). Patients with osteitis fibrosa had urinary N-telopeptide levels that were significantly higher than those in asymptomatic patients (501.5 +/- 201.7 versus 51.3 +/- 6.4 nmol/mmol creatinine; P = 0.02) and those in patients with renal stone disease (P = 0.01). CONCLUSION: The findings in this study demonstrate that vitamin D deficiency or insufficiency may contribute to disease severity in primary hyperparathyroidism.
Francisco Bandeira; Gustavo Caldas; Eduardo Freese; Luiz Griz; Manuel Faria; Cristina Bandeira
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  8     ISSN:  1530-891X     ISO Abbreviation:  Endocr Pract     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-08-13     Completed Date:  2003-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-70     Citation Subset:  IM    
Department of Medicine, Endocrine Unit, Agamenon Magalhães Hospital, Secretary of Health/University of Pernambuco, Recife, Brazil.
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MeSH Terms
Bone Density
Calcifediol / blood*
Collagen / urine
Collagen Type I
Hyperparathyroidism / complications*,  pathology,  physiopathology*
Kidney Calculi / complications
Middle Aged
Osteitis Fibrosa Cystica / complications
Parathyroid Hormone / blood
Peptides / urine
Reg. No./Substance:
0/Collagen Type I; 0/Parathyroid Hormone; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 19356-17-3/Calcifediol; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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