| Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aorta. | |
| | |
MedLine Citation:
|
PMID: 20636707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: We conducted a cross-sectional analysis in a population-based cohort to compare the strength of the associations among various lipid parameters and the presence of atherosclerotic plaque in the proximal thoracic aorta. METHODS: As part of Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects were studied (mean age 69.1 +/- 9.0, 251 males and 213 females), including 255 patients with first ischaemic stroke and 209 stroke-free controls. Presence and thickness of atherosclerotic plaque were assessed by transoesophageal echocardiography. Measured lipid parameters included total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein (Apo) B and A-I levels with their ratio. RESULTS: Overall, atherosclerotic plaque was detected in 326 subjects (70.4%) and 37.6% of these subjects (n=174) had atherosclerotic plaque > or =4 mm. After adjusting for other significant predictors of atherosclerosis, high-density lipoprotein cholesterol level and Apo B/A-I ratio emerged as the strongest predictors of any atherosclerotic plaque (P<0.001 and P=0.004, respectively), followed by individual Apo B (P=0.015) and A-I (P=0.016) levels, triglycerides (P=0.027) and non-high-density lipoprotein cholesterol level (P=0.021). Total and low-density lipoprotein cholesterol levels were not significant predictors for any atherosclerotic plaque (P=0.273 and P=0.081, respectively). High-density lipoprotein cholesterol level (P=0.008) and Apo A-I (P=0.006) were also significant predictors of atherosclerotic plaque > or =4 mm. Similar trends were observed after exclusion of subjects on cholesterol lowering drugs. CONCLUSION: High-density lipoprotein cholesterol level and Apo B/A-I ratio, but not total or low-density lipoprotein cholesterol levels, were strongly associated with degree of proximal aortic atherosclerosis. |
| | |
Authors:
|
Shun Kohsaka; Zhezhen Jin; Tatjana Rundek; Shunichi Homma; Ralph L Sacco; Marco R Di Tullio |
Related Documents
:
|
9712347 - Lipid and lipoprotein levels remain stable in acute ischemic stroke: the northern manha... 2343347 - Safety, tolerability and efficacy of acipimox in type ii hyperlipidaemia. 9015467 - Comparative efficacy and safety of ciprofibrate and sustained-release bezafibrate in pa... 20382637 - Effects of toremifene and tamoxifen on lipid profiles in post-menopausal patients with ... 16822337 - In vitro capacitation of bull spermatozoa by oviductal fluid and its components. 17615007 - Rate of metabolic decarboxylation of leucine as assessed by a l[1-(13)c(1)]leucine brea... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: International journal of stroke : official journal of the International Stroke Society Volume: 5 ISSN: 1747-4949 ISO Abbreviation: Int J Stroke Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-19 Completed Date: 2010-10-28 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 101274068 Medline TA: Int J Stroke Country: England |
Other Details:
|
Languages: eng Pagination: 257-63 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Division of Cardiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Anatomy, Cross-Sectional Anticholesteremic Agents / therapeutic use Aorta, Thoracic / pathology* Apolipoprotein A-I / blood Apolipoproteins B / blood Atherosclerosis / pathology* Cholesterol, HDL / blood Echocardiography, Transesophageal Female Humans Lipids / blood* Lipoprotein(a) / blood Male Middle Aged New York City / epidemiology Prognosis Risk Factors Stroke / epidemiology, pathology*, prevention & control Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
|
R01 29993//PHS HHS; R01 NS 36286/NS/NINDS NIH HHS; R01 NS036286-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anticholesteremic Agents; 0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Lipids; 0/Lipoprotein(a); 0/Triglycerides |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stroke: working toward a prioritized world agenda.
Next Document: Snoring and insomnia are not associated with subclinical atherosclerosis in the Northern Manhattan S...