Document Detail

Relationship between serum levels of macrophage migration inhibitory factor and the activity of antineutrophil cytoplasmic antibody-associated vasculitides.
MedLine Citation:
PMID:  16391884     Owner:  NLM     Status:  MEDLINE    
Macrophage migration inhibitory factor (MIF) is a central proinflammatory cytokine that regulates innate and adaptive immune responses. To evaluate its role in primary vasculitides, we determined MIF by enzyme-linked immunoassay in the sera of patients with Wegener's granulomatosis (WG; n=26), microscopic polyangiitis (MPA; n=10), polyarteritis nodosa (PAN; n=9) and giant cell arteritis (GCA; n=11). Healthy controls (n=26) and patients with sarcoidosis (n=14) were studied in parallel. Serum levels of MIF were significantly higher in patients with WG (median 41.1, range 3.2-120 ng/ml) than those in healthy controls (6.0, 0.015-36.5 ng/ml; P<0.001) and in patients with sarcoidosis (13.8, 0.015-67.1 ng/ml; P<0.05). MIF values were higher in MPA patients (29.5, 9.9-69.4 ng/ml; P<0.01) in comparison with those in healthy controls. In particular, increased levels of MIF were associated with active disease as assessed by the Birmingham Vasculitis Activity Score. Sequential studies showed decreased levels of MIF after initiation of immunosuppressive therapy, with clinical improvement in WG and MPA patients. In contrast, serum levels of MIF were not significantly elevated in patients with PAN and GCA. The results suggest that MIF contributes to the inflammatory process and correlates with disease activity in antineutrophil cytoplasmic antibody-associated vasculitides.
Heidemarie Becker; Christian Maaser; Eva Mickholz; Anke Dyong; Wolfram Domschke; Markus Gaubitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-04
Journal Detail:
Title:  Clinical rheumatology     Volume:  25     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-10-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  368-72     Citation Subset:  IM    
Department of Medicine B, University of Muenster, Albert-Schweitzer-Strasse 33, 48129 Münster, Germany.
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MeSH Terms
Antibodies, Antineutrophil Cytoplasmic / blood*
Giant Cell Arteritis / blood,  complications,  pathology
Macrophage Migration-Inhibitory Factors / blood*
Middle Aged
Peroxidase / immunology
Polyarteritis Nodosa / blood,  complications,  pathology
Reference Values
Sarcoidosis / blood,  complications,  pathology
Serine Endopeptidases / immunology
Vasculitis / blood*,  diagnosis,  etiology
Wegener Granulomatosis / blood,  complications,  pathology
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic; 0/Macrophage Migration-Inhibitory Factors; EC; EC 3.4.21.-/Serine Endopeptidases; EC

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