Document Detail

Relationship between serum inositol concentration and development of retinopathy of prematurity: a prospective study.
MedLine Citation:
PMID:  10779265     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine the relationship between the intake of sugar inositol, serum inositol levels, and ROP in three groups of low birthweight infants receiving feedings containing various concentrations of inositol. METHODS: Infants with a birthweight <1500 g, with severe lung disease, were eligible for the study when they began enteral feedings. Infant formulas contained three different inositol concentrations: 2500, 710, and 242 micromol/L. Serum inositol concentrations were averaged over specific time intervals. A logistic regression model was used to investigate the confounding effect of duration of mechanical ventilation and oxygen therapy, birthweight, Apgar score, and serum inositol concentration on development of ROP. RESULTS: Infants receiving high inositol formula and with higher serum inositol concentrations at birth and after 30 days had a statistically significant lower incidence of severe ROP than those receiving the lower inositol formula and with lower serum concentrations (P<.05). The effective serum inositol concentration (EC90) associated with lesser disease was >215 micromol/L. By logistic regression, the odds of developing severe ROP were greater among infants with low serum inositol concentration (odds ratio=4.7, 95% confidence interval 0.90-24.8, P=.017). CONCLUSION: Inositol supplementation may help prevent the most severe form of ROP.
C A Friedman; J McVey; M J Borne; M James; W L May; D M Temple; K K Robbins; C J Miller; J E Rawson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  37     ISSN:  0191-3913     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    2000 Mar-Apr
Date Detail:
Created Date:  2000-06-01     Completed Date:  2000-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-86     Citation Subset:  IM    
Division of Newborn Medicine, Methodist Medical Center, Jackson, Miss, USA.
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MeSH Terms
Dietary Carbohydrates / administration & dosage*
Enteral Nutrition
Gestational Age
Infant Food*
Infant, Low Birth Weight
Infant, Newborn
Inositol / administration & dosage,  blood*
Prospective Studies
Retinopathy of Prematurity / blood*,  etiology,  prevention & control*
Reg. No./Substance:
0/Dietary Carbohydrates; 6917-35-7/Inositol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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