| Relationship between salivary IgA secretion and upper respiratory tract infection following a 160-km race. | |
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MedLine Citation:
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PMID: 16596116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The relationship between salivary IgA secretion rate and upper respiratory tract infection (URTI) was studied in 155 ultramarathoners (126 males, 29 females, mean age 46.5+/-0.7 y) who had qualified to run the 160-km 2003 Western States Endurance Run. METHODS: Subjects provided saliva samples during registration, held the morning before the race, and within 5-10 minutes postrace (mean race time, 26.2+/-0.3 h). Unstimulated saliva was collected by expectoration for 4 minutes into 15-mL plastic, sterilized vials. Runners finishing the race and providing pre- and postrace saliva samples (n=106) turned in a health log specifying URTI episodes and severity of symptoms for the 2-week period following the race. RESULTS: The total volume of saliva that the runners was able to expectorate during sample collection decreased 51% postrace compared to prerace values (P<0.001). Saliva protein concentration increased 20% (P<0.001) while the saliva protein IgA concentration decreased 10% (P<0.05). Salivary IgA secretion rate decreased 46% when comparing pre- to postrace values (P<0.001). Twenty-four percent of the runners finishing the race and providing salivary samples reported an URTI episode lasting 2 days or longer during the 2-week period following the race (mean number of days with symptoms was 5.4+/-0.6 days). The decrease in salivary IgA secretion rate (pre- to postrace) was 53% greater in the 25 runners reporting URTI (-355+/-45 microg/min) compared to the 81 runners not reporting URTI (-232+/-37 microg/min), (P=0.04). CONCLUSIONS: In summary, nearly 1 in 4 runners reported an URTI episode during the 2-week period following a 160-km race, and the decrease in salivary IgA secretion rate was significantly greater in these runners compared to those not reporting URTI. |
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Authors:
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D C Nieman; D A Henson; C L Dumke; R H Lind; L R Shooter; S J Gross |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of sports medicine and physical fitness Volume: 46 ISSN: 0022-4707 ISO Abbreviation: J Sports Med Phys Fitness Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-04-05 Completed Date: 2006-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376337 Medline TA: J Sports Med Phys Fitness Country: Italy |
Other Details:
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Languages: eng Pagination: 158-62 Citation Subset: IM |
Affiliation:
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Department of Health, Leisure and Exercise Science, Appalachian State University, Boone, NC 28608, USA. niemandc@appstate.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Immunoglobulin A / metabolism* Male Middle Aged Respiratory Tract Infections / immunology* Running / physiology* Saliva / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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