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Relationship between renal function and the risk of recurrent atrial fibrillation following catheter ablation.
MedLine Citation:
PMID:  21062773     Owner:  NLM     Status:  In-Process    
BACKGROUND: Although several clinical variables are associated with the recurrence of atrial fibrillation (AF) following catheter ablation, the influence of renal function remains to be determined.
OBJECTIVE: To evaluate the association of renal function with the outcome of the paroxysmal AF ablation.
METHODS: 224 patients underwent catheter ablation for paroxysmal AF. The relationship between the pre-procedural clinical valuables and ablation outcomes was evaluated.
RESULTS: Over the course of 37.4±24.4 months of follow-up of catheter ablation procedures for AF (mean number of procedures 1.33±0.45), 91.1% of patients (204/224) became free from AF without antiarrhythmic drugs. The estimated glomerular filtration rate (eGFR) was lower in patients with recurrent AF than in those without recurrence (66.6±17.5 vs 78.4±16.8 ml/min/1.73 m(2), p=0.003). AF recurred more frequently in patients with low eGFR (<60 ml/min/1.73 m(2)) than in those with high eGFR (>60 ml/min/1.73 m(2); 24.3% vs 6.7%, p=0.006). Among the various clinical factors, low eGFR (p=0.02) and left atrium (LA) dilatation (p=0.002) independently predicted the clinical outcome of ablation in patients with paroxysmal AF.
CONCLUSION: Low eGFR and LA dilatation independently influence the outcome of catheter ablation for paroxysmal AF.
Michifumi Tokuda; Teiichi Yamane; Seiichiro Matsuo; Keiichi Ito; Ryohsuke Narui; Mika Hioki; Shin-Ichi Tanigawa; Tokiko Nakane; Seigo Yamashita; Keiichi Inada; Kenri Shibayama; Satoru Miyanaga; Hiroshi Yoshida; Hidekazu Miyazaki; Taro Date; Takashi Yokoo; Michihiro Yoshimura
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Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  97     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  AIM; IM    
Department of Cardiology, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan.
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