| Relationship between regional cerebral blood flow and electrocorticographic activities under sevoflurane and isoflurane anesthesia. | |
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MedLine Citation:
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PMID: 20505374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aims of this study are (1) to assess the effects of volatile anesthetics on regional cerebral blood flow (rCBF) and electrocorticography (ECoG), and (2) to investigate the relationship between rCBF and ECoG influenced by volatile anesthetics. The authors measured rCBF using laser Doppler flowmetry and ECoG simultaneously and continuously from the same cortex during craniotomy, using the specially arranged probe. Patients received intravenous anesthetics with nitrous oxide until craniotomy, and after opening of dura, volatile anesthetic, either isoflurane or sevoflurane, was started and was gradually increased for the measurement. Four of the nine cases (44.4%) of the sevoflurane group showed no change both in rCBF and ECoG. In three cases (33.3%), rCBF increased as the frequency of the paroxysmal activities increased. In two cases (22.2%), decreased rCBF was accompanied by slow waves. In 12 cases of the isoflurane group, no apparent rCBF and ECoG changes were seen, except a case with decreased rCBF and slow waves. This is the first report of simultaneous recordings of regional CBF and neuronal activity under general anesthesia. During sevoflurane and isoflurane anesthesia <2.5 minimum alveolar anesthetic concentration, rCBF is affected by ECoG activities rather than pharmacologic action of inhalational anesthetics. |
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Authors:
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Kimiko Fukui; Takato Morioka; Kimiaki Hashiguchi; Tadao Kawamura; Kazuo Irita; Sumio Hoka; Tomio Sasaki; Shosuke Takahashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society Volume: 27 ISSN: 1537-1603 ISO Abbreviation: J Clin Neurophysiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8506708 Medline TA: J Clin Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 110-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan. kimiko.fukui@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Anesthesia, General Anesthetics, Inhalation / pharmacology* Anesthetics, Intravenous / pharmacology Brain / drug effects*, physiopathology*, surgery Cerebrovascular Circulation / drug effects* Craniotomy Electroencephalography Female Humans Isoflurane / pharmacology* Male Methyl Ethers / pharmacology* Middle Aged Regional Blood Flow / drug effects Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Methyl Ethers; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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