Document Detail


Relationship between radial and central arterial pulse wave and evaluation of central aortic pressure using the radial arterial pulse wave.
MedLine Citation:
PMID:  17510503     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since a decrease of central aortic pressure contributes to the prevention of cardiovascular events, simple measurement of not only brachial blood pressure but also central aortic pressure may be useful in the prevention and treatment of cardiovascular diseases. In this study, we simultaneously measured radial artery pulse waves non-invasively and ascending aortic pressure invasively, before and after the administration of nicorandil. We then compared changes in central aortic pressure and radial arterial blood pressure calibrated with brachial blood pressure in addition to calculating the augmentation index (AI) at the aorta and radial artery. After nicorandil administration, the reduction in maximal systolic blood pressure in the aorta (Deltaa-SBP) was -14+/-15 mmHg, significantly larger than that in early systolic pressure in the radial artery (Deltar-SBP) (-9+/-12 mmHg). The reduction in late systolic blood pressure in the radial artery (Deltar-SBP2) was -15+/-14 mmHg, significantly larger than Deltar-SBP, but not significantly different from Deltaa-SBP. There were significant relationships between Deltaa-SBP and Deltar-SBP (r=0.81, p<0.001), and between Deltaa-SBP and Deltar-SBP2 (r=0.91, p<0.001). The slope of the correlation regression line with Deltar-SBP2 (0.83) was larger and closer to 1 than that with Deltar-SBP (0.63), showing that the relationship was close to 1:1. Significant correlations were obtained between aortic AI (a-AI) and radial AI (r-AI) (before nicorandil administration: r=0.91, p<0.001; after administration: r=0.70, p<0.001). These data suggest that the measurement of radial artery pulse wave and observation of changes in the late systolic blood pressure in the radial artery (r-SBP2) in addition to the ordinary measurement of brachial blood pressure may enable a more accurate evaluation of changes in maximal systolic blood pressure in the aorta (a-SBP).
Authors:
Kenji Takazawa; Hideyuki Kobayashi; Naohisa Shindo; Nobuhiro Tanaka; Akira Yamashina
Related Documents :
16291473 - Best reproducibility of the ankle-arm index was calculated using doppler and dividing h...
9709393 - Effect of respiratory rate on the relationships between rr interval and systolic blood ...
19905743 - New possible quark-hadron mixed phase in protoneutron stars.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  30     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  219-28     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Tokyo Medical University Hachioji Medical Center, Japan. takazawa@tokyo-med.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Antihypertensive Agents / pharmacology
Aorta / drug effects,  physiology*
Blood Pressure / drug effects,  physiology*
Brachial Artery / drug effects,  physiology*
Calibration
Female
Humans
Hypertension / physiopathology
Male
Manometry / methods
Middle Aged
Nicorandil / pharmacology
Radial Artery / drug effects,  physiology*
Regional Blood Flow / drug effects,  physiology
Regression Analysis
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 65141-46-0/Nicorandil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on...
Next Document:  Relationship between visceral fat and cardiovascular disease risk factors: the Tanno and Sobetsu stu...