Document Detail

Relationship between pulmonary artery volumes at computed tomography and pulmonary artery pressures in patients with- and without pulmonary hypertension.
MedLine Citation:
PMID:  17913425     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was designed to determine the relationship between pulmonary artery (PA) volumes at computed tomography (CT) and PA pressures at right-sided heart catheterization in patients with and without pulmonary hypertension (PAH) to develop a noninvasive CT method of PA pressure quantification. MATERIALS AND METHODS: Sixteen patients with chronic sleep apnea syndrome underwent contrast enhanced helical CT (slice thickness 3mm; pitch 2; increment 2mm) at inspiration. Eight patients had PAH while cardiopulmonary disease has been excluded in eight other patients. Vascular volumes were determined using a 3D technique (threshold seeded vascular tracing algorithm; thresholds -600 H [lower] and 3,000 H [upper]). Right-sided heart catheterization measurements were available for linear regression analysis of PA volumes and pressures. RESULTS: Correlation between PA pressures and volumes (normalized for BMI), was high in both groups (without PAH: r=.85; with PAH .90, Pearson). Compared to elevated PA pressures in patients with pulmonary hypertension (p<.005), PA volumes also were significantly increased (p<.05) among the groups. CONCLUSIONS: High correlation was found between PA volumes and mean PA pressures in patients with- and without PAH. Significant differences in PA volumes at CT-volumetry may admit non-invasive determination of pulmonary hypertension.
Jens J Froelich; Helmut Koenig; Lennard Knaak; Stefan Krass; Klaus J Klose
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-29
Journal Detail:
Title:  European journal of radiology     Volume:  67     ISSN:  0720-048X     ISO Abbreviation:  Eur J Radiol     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-18     Completed Date:  2009-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  466-71     Citation Subset:  IM    
Department of Radiology, Philipps-University Hospital, Baldingerstrasse, 35043 Marburg, Germany.
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MeSH Terms
Blood Pressure*
Hypertension, Pulmonary / physiopathology*,  radiography*
Middle Aged
Organ Size
Pulmonary Artery / physiopathology*,  radiography*
Statistics as Topic
Tomography, X-Ray Computed / methods*

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