Document Detail


Relationship between psychological stress and reproductive outcome in women undergoing in vitro fertilization treatment: psychological and neurohormonal assessment.
MedLine Citation:
PMID:  23212833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate whether psychological stress, as well as changes in hypothalamus-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) at different time points during a first in vitro fertilization (IVF) cycle, correlates with the reproductive outcome.
METHODS: A prospective study was conducted in 264 women undergoing IVF or intracytoplasmic sperm injection (ICSI) treatment between January 2009 and March 2010. Standardized psychological questionnaires were used to assess anxiety and depression. Norepinephrine and cortisol in serum were measured with specific assays.
RESULTS: The non-pregnant women reported higher anxiety and depression scores at the pregnancy detection day compared with the pregnant group. Lower levels of norepinephrine and cortisol at the time of oocyte retrieval and lower levels of cortisol at the time of pregnancy test were found in women with successful treatment. Significant increases in serum norepinephrine and cortisol values were observed during ovarian stimulation. State Anxiety scores were negatively correlated with live birth rate, and positively associated with serum norepinephrine and cortisol values.
CONCLUSIONS: State anxiety is associated with both pregnancy rate and live birth rate in IVF patients, an effect that is partly mediated by activities in the HPA and SNS.
Authors:
Yuan An; Zhuangzhuang Sun; Linan Li; Yajuan Zhang; Hongping Ji
Related Documents :
24348873 - Enablers of and barriers to making healthy change during pregnancy in overweight and ob...
1610503 - Hypoplasia of the lung and heart in fetal rats with diaphragmatic hernia.
9764863 - Serum ca 125 and first trimester abortion.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-05
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  30     ISSN:  1573-7330     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-24     Completed Date:  2013-07-22     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety / psychology
Depression / psychology
Female
Fertilization in Vitro / psychology*
Humans
Hydrocortisone / blood
Hypothalamo-Hypophyseal System / physiology
Live Birth
Multivariate Analysis
Norepinephrine / blood
Oocyte Retrieval
Ovulation Induction / adverse effects
Pituitary-Adrenal System / physiology
Pregnancy
Pregnancy Outcome / psychology*
Pregnancy Rate
Prospective Studies
Questionnaires
Stress, Psychological*
Sympathetic Nervous System / physiology
Time Factors
Chemical
Reg. No./Substance:
WI4X0X7BPJ/Hydrocortisone; X4W3ENH1CV/Norepinephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Starting and resulting testosterone levels after androgen supplementation determine at all ages in v...
Next Document:  Prevalence of subclinical mastitis and isolated udder pathogens in dairy cows in Southern Vietnam.