Document Detail

Relationship between pronuclear scoring and embryo quality and implantation potential in IVF-ET.
MedLine Citation:
PMID:  18480999     Owner:  NLM     Status:  MEDLINE    
To assess the relationship between pronuclear scoring and day-3 embryo quality and pregnancy outcome and to determine the clinical value of pronuclear stage scoring system in human in vitro fertilization-embryo transfer (IVF-ET) program, a pronuclear scoring system was used to score zygotes 16-20 h after insemination during conventional IVF or intracytoplasmic sperm injection (ICSI). The embryos were classified into groups Z1, Z2, Z3 and Z4. Comparisons were made of the rates of arrested embryos and excellent embryos on day 3. Comparisons of pregnancy outcome were made only in those patients in whom cohorts of similarly Z-scored embryos were transferred. The results showed that there were less arrested embryos and more excellent embryos on day 3 in groups Z1 and Z2 than those in group Z3 and Z4. More embryos arrested and less excellent embryos developed in group Z4 than group Z3. The clinical pregnancy rates resulting from the transfer of single pronuclear score homologous embryo types were similar among groups Z1, Z2 and Z3. Implantation rates of group Z1 were higher (P<0.05) than that of group Z3. These findings suggests that pronuclear scoring can predict developmental ability on day 3 and implantation potential. A evaluation that combines the Z-score and day 3 embryo morphology is useful in the determination of the most viable embryos and the number of embryos for transfer.
Qun Liu; Guijin Zhu; Juan Hu; Yulan Wei; Xinling Ren; Hanwang Zhang; Yufeng Li; Lei Jin; Jing Yue
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Publication Detail:
Type:  Journal Article     Date:  2008-05-15
Journal Detail:
Title:  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban     Volume:  28     ISSN:  1672-0733     ISO Abbreviation:  J. Huazhong Univ. Sci. Technol. Med. Sci.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101169627     Medline TA:  J Huazhong Univ Sci Technolog Med Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  204-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
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MeSH Terms
Cell Nucleus / metabolism*
Embryo Implantation
Embryo Transfer / methods*
Fertilization in Vitro*
Infertility / therapy
Models, Biological
Oocytes / metabolism
Ovary / metabolism*
Pregnancy Outcome
Spermatozoa / metabolism

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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