| Relationship between pro-anti-inflammatory cytokines, T-cell activation and CA 125 in obese patients with heart failure. | |
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MedLine Citation:
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PMID: 21358606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This researcher previously found that serum levels of some inflammatory cytokines are elevated in patients with cardiovascular disease (CVD). Hence, this study investigated the relationship between circulating levels of pro-anti-inflammatory cytokines, T-cell activation marker and carbohydrate antigen 125 (CA 125) for the first time in obese Egyptian patients with heart failure (HF). MATERIAL/METHODS: This study included 60 HF patients, and 30 normal controls, with age range 50-70 years. HF patients were divided into 2 groups: non-obese mild HF according to clinical status (New York Heart Association Class) (NYHA class I/II) (n = 20) and obese severe HF (NYHA class III/IV) (n = 40). Serum pro-anti-inflammatory cytokine levels (TNF-α, IL-6, and IL-10), T-cell activation marker (sIL-2R/CD25), and CA 125; tumor marker were measured by ELISA. RESULTS: Serum levels of TNF-α, IL-6, and IL-10 as pro-anti-inflammatory cytokines, sIL-2R/CD25 as T-cell activation marker, and CA 125 as tumor marker were significantly higher in HF patients than in normal controls. Moreover, serum levels of TNF-α, IL-6, sIL-2R/CD25, and IL-10, as well as CA 125 were significantly higher in the obese than in the non-obese mild HF patients. Correlation analysis showed that CA 125 was positively related to BMI, TNF-α, IL-6, and sIL-2R/CD25 in the HF patients group. CONCLUSIONS: These findings show that CA 125 is markedly elevated in HF patients, and is correlated with serum TNF-α, IL-6, and sIL-2R/CD25 levels. Therefore, we can conclude that CA125, being a tumor marker, is closely related to the cytokine system. |
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Authors:
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Nadia M Hamdy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 17 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2011-06-21 Revised Date: 2011-09-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR174-9 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Ain Shams University, Faculty of Pharmacy, Cairo, Egypt. adia_hamdy@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged CA-125 Antigen / blood* Case-Control Studies Cytokines / blood* Female Heart Failure / blood, complications, immunology*, physiopathology Hemodynamics Humans Inflammation Mediators / blood* Lymphocyte Activation / immunology* Male Middle Aged Obesity / blood, complications, immunology* T-Lymphocytes / immunology* |
| Chemical | |
Reg. No./Substance:
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0/CA-125 Antigen; 0/Cytokines; 0/Inflammation Mediators |
| Comments/Corrections | |
Comment In:
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Med Sci Monit. 2011 Aug 1;17(8):LE5-6
[PMID:
21804472
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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