Document Detail

Relationship between pro-anti-inflammatory cytokines, T-cell activation and CA 125 in obese patients with heart failure.
MedLine Citation:
PMID:  21358606     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This researcher previously found that serum levels of some inflammatory cytokines are elevated in patients with cardiovascular disease (CVD). Hence, this study investigated the relationship between circulating levels of pro-anti-inflammatory cytokines, T-cell activation marker and carbohydrate antigen 125 (CA 125) for the first time in obese Egyptian patients with heart failure (HF).
MATERIAL/METHODS: This study included 60 HF patients, and 30 normal controls, with age range 50-70 years. HF patients were divided into 2 groups: non-obese mild HF according to clinical status (New York Heart Association Class) (NYHA class I/II) (n = 20) and obese severe HF (NYHA class III/IV) (n = 40). Serum pro-anti-inflammatory cytokine levels (TNF-α, IL-6, and IL-10), T-cell activation marker (sIL-2R/CD25), and CA 125; tumor marker were measured by ELISA.
RESULTS: Serum levels of TNF-α, IL-6, and IL-10 as pro-anti-inflammatory cytokines, sIL-2R/CD25 as T-cell activation marker, and CA 125 as tumor marker were significantly higher in HF patients than in normal controls. Moreover, serum levels of TNF-α, IL-6, sIL-2R/CD25, and IL-10, as well as CA 125 were significantly higher in the obese than in the non-obese mild HF patients. Correlation analysis showed that CA 125 was positively related to BMI, TNF-α, IL-6, and sIL-2R/CD25 in the HF patients group.
CONCLUSIONS: These findings show that CA 125 is markedly elevated in HF patients, and is correlated with serum TNF-α, IL-6, and sIL-2R/CD25 levels. Therefore, we can conclude that CA125, being a tumor marker, is closely related to the cytokine system.
Nadia M Hamdy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  17     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-06-21     Revised Date:  2011-09-14    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR174-9     Citation Subset:  IM    
Department of Biochemistry, Ain Shams University, Faculty of Pharmacy, Cairo, Egypt.
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MeSH Terms
CA-125 Antigen / blood*
Case-Control Studies
Cytokines / blood*
Heart Failure / blood,  complications,  immunology*,  physiopathology
Inflammation Mediators / blood*
Lymphocyte Activation / immunology*
Middle Aged
Obesity / blood,  complications,  immunology*
T-Lymphocytes / immunology*
Reg. No./Substance:
0/CA-125 Antigen; 0/Cytokines; 0/Inflammation Mediators
Comment In:
Med Sci Monit. 2011 Aug 1;17(8):LE5-6   [PMID:  21804472 ]

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