Document Detail

Relationship between plasma phospholipid polyunsaturated fatty acid composition and bone disease in renal transplantation.
MedLine Citation:
PMID:  16314806     Owner:  NLM     Status:  MEDLINE    
To investigate the relationship between polyunsaturated fatty acid (PUFA) and bone metabolism in renal transplant patients, plasma phospholipid (PP) PUFA levels, biochemical markers of bone turnover and bone mineral density (BMD) were determined in 22 recipients of a first renal allograft at baseline and after a mean 24.4 month follow-up. A significant increase in PP n-3 PUFA content, in the [n-3 PUFA/ arachidonic acid] ratio and in BMD values was observed, as well as a close correlation between the increase in PP n-3 PUFA content and femoral neck BMD. Multivariate regression analysis showed that BMD improvement was positively related to PP n-3 PUFA variation and baseline PP eicosapentaenoic acid levels, and negatively to PP arachidonic acid modification. Tacrolimus- versus cyclosporine-treated patients demonstrated a significant increase in femoral neck BMD and PP n-3 PUFA content. This is the first longitudinal study showing a link between PP-PUFA composition and bone disease in renal transplantation.
Bruno Baggio; Alessandro Budakovic; Alberto Ferraro; Simone Checchetto; Giovanna Priante; Estella Musacchio; Enzo Manzato; Martina Zaninotto; Maria-Cristina Maresca
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation     Volume:  80     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-29     Completed Date:  2006-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1349-52     Citation Subset:  IM    
Department of Medical and Surgical Sciences, University of Padova, and Central Laboratory, University Hospital of Padova, Italy.
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MeSH Terms
Arachidonic Acid / blood
Biological Markers / blood
Bone Density
Bone Diseases / etiology*
Bone Remodeling
Cyclosporine / therapeutic use
Fatty Acids, Omega-3 / blood
Fatty Acids, Unsaturated / blood*
Femur Neck / metabolism
Immunosuppressive Agents / therapeutic use
Kidney Transplantation / adverse effects*
Longitudinal Studies
Middle Aged
Phospholipids / blood*
Tacrolimus / therapeutic use
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Immunosuppressive Agents; 0/Phospholipids; 109581-93-3/Tacrolimus; 506-32-1/Arachidonic Acid; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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