Document Detail


Relationship between plasma levels of procainamide, suppression of premature ventricular complexes and prevention of recurrent ventricular tachycardia.
MedLine Citation:
PMID:  7249296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We compared the relationship between plasma levels of procainamide and suppression or prevention of various forms of ventricular arrhythmias in 18 patients, six of whom had premature ventricular complexes (PVCs) during acute myocardial infarction (AMI), six of whom had PVCs in the setting of stable chronic ischemic heart disease (CIHD), and six of whom had recurrent symptomatic ventricular tachycardia (VT) with chronic PVCs between episodes of VT. The mean plasma level of procainamide required for 85% suppression of PVCs in the AMI patients was 5.0 +/- 0.5 micrograms/ml, while that required for the CIHD patients was 9.3 +/- 0.7 micrograms/ml (p less than 0.05). The mean plasma level required for prevention of spontaneous episodes of symptomatic sustained tachycardia in the VT group was 9.1 +/- 3.4 micrograms/ml, while the mean level required for 85% suppression of PVCs in the same patients was 14.9 +/- 3.8 micrograms/ml (p less than 0.01). In the VT group, PVC frequency was decreased by a mean of only 36% (range 11-63%) at plasma levels of procainamide sufficient to prevent spontaneous VT. The relationship between plasma levels of procainamide and PVC suppression appears to be different in AMI and CIHD patients; furthermore, a high degree of PVC suppression is not a necessary endpoint of antiarrhythmic therapy when attempting to protect patients against recurrent symptomatic VT.
Authors:
R J Myerburg; K M Kessler; I Kiem; K C Pefkaros; C A Conde; D Cooper; A Castellanos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  64     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-25     Completed Date:  1981-09-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  280-90     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Chronic Disease
Coronary Disease / drug therapy
Dose-Response Relationship, Drug
Electrocardiography*
Female
Heart Ventricles / physiopathology
Humans
Male
Middle Aged
Myocardial Infarction / drug therapy
Procainamide / blood*,  therapeutic use
Recurrence
Tachycardia / drug therapy*
Grant Support
ID/Acronym/Agency:
HL 18769-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
51-06-9/Procainamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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