| Relationship between plasma and brain large neutral amino acids in rats fed diets with different compositions at different times of the day. | |
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MedLine Citation:
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PMID: 1402929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Large neutral amino acids (LNAAs) compete with each other for carrier-mediated transport through the blood-brain barrier into the brain. The relative plasma concentration, expressed as the ratio of each LNAA to the sum of LNAAs, is considered the main regulator of brain LNAA concentrations. In order to investigate the consistency of this assumption throughout a 24-h period, we have compared the relationship of plasma LNAAs to brain LNAAs among groups of rats fed diets containing various amounts of protein (in order to obtain a wide range of plasma LNAA levels) at two different phases of the light/dark cycle (0900 and 2100 hours). The relationship between plasma and brain LNAAs was found to be dependent on both diet and the time of day. Similar plasma amino acid concentrations in the morning and in the evening contrasted with different brain concentrations. Furthermore, previous findings that brain LNAA concentrations are influenced by plasma amino acid concentrations were confirmed. |
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Authors:
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L Voog; T Eriksson |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neurochemistry Volume: 59 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1992-11-20 Completed Date: 1992-11-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1868-74 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Amino Acids / blood*, classification, physiology Animals Brain / metabolism*, physiology Brain Chemistry / drug effects* Circadian Rhythm* / drug effects Dietary Proteins / classification, pharmacology* Male Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Dietary Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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