Document Detail

Relationship between plasma and brain large neutral amino acids in rats fed diets with different compositions at different times of the day.
MedLine Citation:
PMID:  1402929     Owner:  NLM     Status:  MEDLINE    
Large neutral amino acids (LNAAs) compete with each other for carrier-mediated transport through the blood-brain barrier into the brain. The relative plasma concentration, expressed as the ratio of each LNAA to the sum of LNAAs, is considered the main regulator of brain LNAA concentrations. In order to investigate the consistency of this assumption throughout a 24-h period, we have compared the relationship of plasma LNAAs to brain LNAAs among groups of rats fed diets containing various amounts of protein (in order to obtain a wide range of plasma LNAA levels) at two different phases of the light/dark cycle (0900 and 2100 hours). The relationship between plasma and brain LNAAs was found to be dependent on both diet and the time of day. Similar plasma amino acid concentrations in the morning and in the evening contrasted with different brain concentrations. Furthermore, previous findings that brain LNAA concentrations are influenced by plasma amino acid concentrations were confirmed.
L Voog; T Eriksson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  59     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-11-20     Completed Date:  1992-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1868-74     Citation Subset:  IM    
Department of Pharmacology, University of Gothenburg, Sweden.
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MeSH Terms
Administration, Oral
Amino Acids / blood*,  classification,  physiology
Brain / metabolism*,  physiology
Brain Chemistry / drug effects*
Circadian Rhythm* / drug effects
Dietary Proteins / classification,  pharmacology*
Rats, Sprague-Dawley
Reg. No./Substance:
0/Amino Acids; 0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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