Document Detail

Relationship between plasma apelin level and coronary collateral circulation.
MedLine Citation:
PMID:  24905139     Owner:  NLM     Status:  Publisher    
OBJECTIVE: Coronary collaterals play a crucial role during an acute ischemic attack. Angiogenesis has an important role in the formation of coronary collateral vessels. Previously, it was shown that apelin is a potential angiogenetic factor. Thus, we aimed to investigate relationship between plasma apelin levels and coronary collateral circulation in patients with stable coronary artery disease.
METHODS: Among patients who underwent coronary angiography with stable angina pectoris, patients with a stenosis of ≥90% were included in our study. Collateral degree was graded according to Rentrop-Cohen classification. Patients with grade 2 or 3 collateral degree were included in good collateral group and patients with grade 0 or 1 collateral degree were included in poor collateral group.
RESULTS: Plasma apelin level was significantly higher in good collateral group (0.69 ± 0.2 vs 0.59 ± 0.2 ng/dl, p < 0.001). Serum nitric oxide levels were similar between two groups. In multivariate regression analysis apelin [6.95 (1.46-33.15), p = 0.015] and presence of total occlusion [4.40 (1.04-18.62), p = 0.044] remained as independent predictors for good coronary collateral development.
CONCLUSIONS: Higher plasma apelin level was related to better coronary collateral development. Demonstration of favorable affects of apelin on good collateral development may lead to consider apelin in antiischemic treatment strategies in order to increase collateral development.
Mehmet Kadri Akboga; Ahmet Akyel; Asife Sahinarslan; Canan Yilmaz Demirtas; Cagri Yayla; Bulent Boyaci; Ridvan Yalcin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-10
Journal Detail:
Title:  Atherosclerosis     Volume:  235     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  289-294     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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