Document Detail

Relationship between plasma antioxidant concentrations and carotid intima-media thickness: the Asymptomatic Carotid Atherosclerotic Disease In Manfredonia Study.
MedLine Citation:
PMID:  19384236     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Few studies have examined the relationship among carotid atherosclerosis, vascular risk factors, and antioxidant plasma concentrations, and those that have reported conflicting results. The aim of this study was to assess the relationship between asymptomatic carotid atherosclerosis, as defined by carotid intima-media thickness (CIMT), and inflammatory markers, plasma lipids and serum antioxidant vitamins. METHODS AND RESULTS: We examined baseline characteristics of the 640 participants in the Asymptomatic Carotid Atherosclerotic Disease In Manfredonia Study. All participants were asymptomatic with respect to carotid artery disease in 2006-2007 and underwent physical examination with carotid ultrasound investigation, the collection of medical history and laboratory data. Analysis of variance methods were used to examine differences between participants by category of CIMT. Of the 640 participants, 291 did not have evidence of carotid atherosclerosis (CIMT<0.8 mm), 232 were found to have some atherosclerosis (0.8 mm< or =CIMT<1.2 mm), and 117 were found to have extensive atherosclerosis (CIMT>1.2 mm). Among participants with CIMT> or =0.8 mm, body mass index, blood pressures, total cholesterol, LDL cholesterol, triglycerides, uric acid, C-reactive protein, and fibrinogen were significantly higher, whereas concentrations of vitamin A, vitamin E, lycopene, and beta-carotene were all significantly lower when compared with participants who did not show evidence of carotid atherosclerosis (P<0.001). CONCLUSION: The optimal control of hypertension, diabetes, and dyslipidemia, in addition to smoking cessation and an adequate intake of antioxidant micronutrients from foods represent a key for the prevention of atherosclerotic disease.
Graziano Riccioni; Nicolantonio D'Orazio; Nicola Palumbo; Valentina Bucciarelli; Emanuela di Ilio; Lydia A Bazzano; Tonino Bucciarelli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology     Volume:  16     ISSN:  1741-8275     ISO Abbreviation:  Eur J Cardiovasc Prev Rehabil     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-17     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101192000     Medline TA:  Eur J Cardiovasc Prev Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  IM    
Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy.
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MeSH Terms
Antioxidants / metabolism*
Biological Markers / blood
Carotenoids / blood
Carotid Arteries / pathology*,  ultrasonography
Carotid Artery Diseases / blood*,  etiology,  pathology*
Cross-Sectional Studies
Diabetes Complications / etiology
Dyslipidemias / etiology
Hypertension / complications
Inflammation Mediators / blood
Lipids / blood
Middle Aged
Nutritional Status
Odds Ratio
Prospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Smoking / adverse effects
Tunica Intima / pathology*,  ultrasonography
Tunica Media / pathology*,  ultrasonography
Vitamin A / blood
Vitamin E / blood
Vitamins / blood*
beta Carotene / blood
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Inflammation Mediators; 0/Lipids; 0/Vitamins; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 502-65-8/lycopene; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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