Document Detail

Relationship between peripheral vascular closure and proliferative retinopathy in sickle cell disease.
MedLine Citation:
PMID:  1765296     Owner:  NLM     Status:  MEDLINE    
In a study involving 97 patients with hemoglobin SC sickle cell disease (Hb SC) and 87 subjects with hemoglobin SS sickle cell disease (Hb SS) on the island of Curaçao, we found a higher incidence of peripheral retinal vascular closure and proliferative retinopathy in the former as compared with the latter. Examination of composite fluorescein angiograms obtained from 15 Hb SS and 36 Hb SC patients, whose mean and median age were the same and in whom more advanced stages of sickle retinopathy were equally represented, revealed statistically significantly smaller measurements of perfused retina (indicative of larger areas of non-perfusion) in Hb SC patients as compared with Hb SS patients (P = 0.002, P = 0.014) as well as in subjects exhibiting neovascularization as compared with those who did not (P = 0.022, P = 0.004). This suggests that a vaso-occlusive tendency in the retina is greater in individuals with Hb SC than in those with Hb SS; the more extensive ischemic areas provide a stimulus for neovascularization, explaining the higher prevalence of proliferative retinopathy in the former patients as compared with the latter.
J C van Meurs
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  229     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-14     Completed Date:  1992-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  543-8     Citation Subset:  IM    
Vitreoretinal Department, Oogziekenhuis, Rotterdam, The Netherlands.
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MeSH Terms
Anemia, Sickle Cell / complications*
Fluorescein Angiography
Fundus Oculi
Netherlands Antilles
Retinal Artery Occlusion / etiology*
Retinal Diseases / etiology*
Retinal Neovascularization / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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