Document Detail

Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography.
MedLine Citation:
PMID:  18338981     Owner:  NLM     Status:  MEDLINE    
Vascular dysfunction in the coronary and peripheral circulations is an early prognostic marker of future cardiovascular events. Measurements of coronary and peripheral vascular function in resistance vessels can be made, but rely on invasive procedures, which make them unsuitable for routine application. An assessment of the direct correlation between vascular responses in skin and coronary vessels has not been made previously. In 27 normal healthy subjects (18-55 years of age), we examined the relationship between peripheral and coronary vascular function. Cutaneous perfusion was measured using the non-invasive technique of laser Doppler imaging during iontophoresis of acetylcholine and sodium nitroprusside, and cutaneous vascular conductance was calculated (laser Doppler perfusion/mean arterial pressure). Coronary flow reserve was measured using transthoracic echocardiography during intravenous adenosine infusion. Mean diastolic velocities were measured at baseline and peak hyperaemic conditions from the Doppler signal recordings. CVR (coronary velocity reserve) was defined as the ratio of hyperaemic to basal mean diastolic velocities. There were significant positive correlations between CVR and cutaneous vascular conductance for acetylcholine (r=0.399, P=0.039) and sodium nitroprusside (r=0.446, P=0.020). These results support the idea that peripheral measurements of skin blood flow are representative of generalized microvascular function including that of the coronary circulation in normal healthy subjects.
Faisel Khan; Dean Patterson; Jill J F Belch; Kumiko Hirata; Chim C Lang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  115     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2008-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
Institute of Cardiovascular Research, University Division of Medicine & Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK.
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MeSH Terms
Acetylcholine / diagnostic use
Adenosine / diagnostic use
Blood Flow Velocity
Coronary Circulation*
Coronary Vessels / physiopathology,  ultrasonography*
Iontophoresis / methods
Laser-Doppler Flowmetry / methods
Middle Aged
Nitroprusside / diagnostic use
Regional Blood Flow
Reproducibility of Results
Skin / blood supply*
Vasodilator Agents / diagnostic use
Grant Support
//Medical Research Council
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine; 58-61-7/Adenosine

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