| Relationship between the perception of dyspnoea and airway inflammatory markers. | |
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MedLine Citation:
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PMID: 11905549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poor dyspnoea perception in asthmatic patients seems to be associated with increased risk of asthma exacerbation. We have studied the relationship between basel ne dyspnoea perception and inflammatory markers in sputum in eight patients with mild asthma and in 13 patients with moderate to severe asthma. The perception of dyspnoea was scored on the Borg scale. Eosinophilic cationic protein (ECP) was measured by fluoroimmunoassay and by an interleukin (IL)-5 sandwich ELISA. The baseline Borg score was significantly higher in patients with severe asthma than in patients with mild to moderate asthma (4.1 +/- 0.29 vs. 2.28 +/- 0.28, P<0.05). The proportion of eosinophil and ECP levels in the sputum were significantly higher in patients with moderate to severe asthma. IL-5 in sputum was significantly increased in moderate to severe asthmatic patients compared to mild asthmatic patients. A significant relationship was found between the baseline perception score and FEV1/FVC (r = -0.53, P<0.01), sputum eosinophils (r = 0.70, P<0.01) and sputum ECP (r = 0.62, P<0.01). These findings suggest that the baseline perception score is related to inflammatory markers in sputum, and that the perception of dyspnoea as well as airway inflammatory markers may be considered to evaluate asthma severity. |
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Authors:
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A S Jang; I S Choi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Respiratory medicine Volume: 96 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-21 Completed Date: 2002-04-25 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
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Languages: eng Pagination: 150-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Seonam University College of Medicine, Seogu, Gwangju, Korea. jas877@chollian.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Antimicrobial Cationic Peptides / analysis Asthma / immunology, physiopathology* Biological Markers / analysis Bronchial Provocation Tests Dyspnea / immunology, physiopathology* Eosinophils / chemistry, pathology Female Humans Male Perception Sputum / chemistry, immunology Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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0/Antimicrobial Cationic Peptides; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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