| Relationship between the paraoxonase (PON1) L55M and Q192R polymorphisms and obesity in a Mexican population: a pilot study. | |
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MedLine Citation:
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PMID: 21484160 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to examine the relationship between the L55M and Q192R paraoxonase (PON1) polymorphisms and obesity in a population of adult Mexican workers. The study population included 127 adult individuals from the Universidad Autónoma del Estado de Morelos, ranging in age from 20 to 56 years and representing both sexes. Based on body mass index, 63 individuals were classified as obese and 64 as normal weight. The PON1-Q192R and PON1-L55M polymorphisms were determined by restriction fragment length polymorphism PCR analysis. Both arylesterase and paraoxonase activity levels were similar in both groups, whereas systolic pressure, triglyceride, total cholesterol, low-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, glucose, and insulin levels were higher in the obese group than in the normal-weight group (P < 0.05). An exception was the high-density lipoprotein cholesterol (HDL-C) levels, which were lower in the obese group (P < 0.05). Although the PON1-Q192R polymorphism was not associated with either group, the frequency of the homozygous L genotype for the PON1-L55M polymorphism was higher in the obese group than in the normal-weight group (P < 0.05). In conclusion, this study established a positive association between the PON1-L55M homozygous L genotype and obesity. |
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Authors:
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Maria Fernanda Martínez-Salazar; Damianys Almenares-López; Sara García-Jiménez; Miguel Angel Sánchez-Alemán; Alina Juantorena-Ugás; Camilo Ríos; Antonio Monroy-Noyola |
Publication Detail:
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Type: Journal Article Date: 2011-03-25 |
Journal Detail:
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Title: Genes & nutrition Volume: 6 ISSN: 1555-8932 ISO Abbreviation: Genes Nutr Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-21 Completed Date: 2011-11-10 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 101280108 Medline TA: Genes Nutr Country: Germany |
Other Details:
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Languages: eng Pagination: 361-8 Citation Subset: - |
Affiliation:
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Laboratorio de Diagnóstico Molecular, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001 Col. Chamilpa, 62209, Cuernavaca, Morelos, México. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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