Document Detail


Relationship between oxidative stress, semen characteristics, and clinical diagnosis in men undergoing infertility investigation.
MedLine Citation:
PMID:  10688996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether particular semen characteristics in various clinical diagnoses of infertility are associated with high oxidative stress and whether any group of infertile men is more likely to have high seminal oxidative stress. Reactive oxygen species (ROS) play an important role in sperm physiological functions, but elevated levels of ROS or oxidative stress are related to male infertility.
DESIGN: Measurement of sperm concentration, motility, morphology, seminal ROS, and total antioxidant capacity (TAC) in patients seeking infertility treatment and controls.
SETTING: Male infertility clinic of a tertiary care center.
PATIENT(S): One hundred sixty-seven infertile patients and 19 controls.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Semen characteristics, seminal ROS, and TAC in samples from patients with various clinical diagnoses and controls.
RESULT(S): Fifteen patients (9.0%) were Endtz positive and 152 (91.0%) Endtz negative. Sperm concentration, motility, and morphology were significantly reduced in all groups compared with the controls (P =.02), except in varicocele associated with infection group. Mean (+/-SD) ROS levels in patient groups ranged from 2.2 +/- 0.13 to 3.2 +/- 0.35, significantly higher than controls (1.3 +/- 0.3; P<.005). Patient groups had a significantly lower mean (+/-SD) TAC from 1014.75 +/- 79.22 to 1173.05 +/- 58.07 than controls (1653 +/- 115.28, P<.001), except in the vasectomy reversal group (1532.02 +/- 74.24). Sperm concentration was negatively correlated with ROS both overall and within all groups (P</=.007), with the exception of idiopathic infertility.
CONCLUSION(S): Irrespective of the clinical diagnosis and semen characteristics, the presence of seminal oxidative stress in infertile men suggests its role in the pathophysiology of infertility. Medical or surgical treatments for infertility in these men should include strategies to reduce oxidative stress.
Authors:
F F Pasqualotto; R K Sharma; D R Nelson; A J Thomas; A Agarwal
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  73     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-23     Completed Date:  2000-03-23     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  459-64     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antioxidants / analysis,  metabolism
Case-Control Studies
Humans
Infection / complications
Infertility, Male / diagnosis*,  etiology,  metabolism*
Leukocytes / enzymology
Male
Male Urogenital Diseases / complications
Oxidative Stress*
Peroxidase / metabolism
Reactive Oxygen Species / metabolism
Reference Values
Semen / physiology*
Sperm Motility
Varicocele / complications
Vasovasostomy
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; EC 1.11.1.7/Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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