| Relationship between osteoporosis and adipose tissue leptin and osteoprotegerin in patients with chronic obstructive pulmonary disease. | |
| | |
MedLine Citation:
|
PMID: 21376149 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
INTRODUCTION: The role of fat-bone interactions in the pathogenesis of osteoporosis in chronic obstructive pulmonary disease (COPD) is poorly understood. Our aim was to investigate expressions of leptin and osteoprotegerin (OPG) in the adipose tissue, and their relationships to osteoporosis in patients with COPD. METHODS: In 39 patients with stable COPD, bone mineral density (BMD) and body composition was assessed by Dual Energy X-Ray Absorptiometry. Serum leptin was determined by the enzyme-linked immunosorbent assay, and bone turnover markers osteocalcin and β-crosslaps by the electrochemiluminiscence immunoassays. Subcutaneous adipose tissue samples were analyzed using real-time PCR. RESULTS: Twenty-one patients without, and 18 with osteoporosis were enrolled (35 men; age 62.2±7.3years). Compared to patients without osteoporosis, those with the disease had significantly lower serum levels and adipose tissue expressions of leptin, in association with increased serum β-crosslaps (p=0.028, p=0.034, p=0.022, respectively). Log adipose tissue leptin was inversely related to serum β-crosslaps (p=0.015), and directly to serum leptin (p<0.001) and to the total, femoral, and lumbar BMD and T-score (p<0.02 for all relationships). Adipose tissue OPG expression was related to all variables of bone density except for lumbar BMD and T-score (p<0.05 for all relationships). Log adipose tissue leptin and OPG expressions predicted femoral T-score independently of age, gender and pulmonary function (p<0.001, adjusted R(2)=0.383; p=0.008, adjusted R(2)=0.301, respectively). Introducing body mass (or fat mass) index into these models eliminated independent predictive value of leptin and OPG expressions. CONCLUSION: Our results suggest that adipose tissue leptin and OPG expressions are related to osteoporosis in patients with COPD, and appear to act as mediators between fat mass and BMD. |
| | |
Authors:
|
Pavol Pobeha; Jozef Ukropec; Peter Skyba; Barbara Ukropcova; Pavol Joppa; Timea Kurdiova; Martin Javorsky; Iwar Klimes; Ivan Tkac; Daniela Gasperikova; Ruzena Tkacova |
Related Documents
:
|
11887039 - Cat-scratch disease in an immunocompromised host. 6986149 - 5-thiopyridoxine in rheumatoid arthritis: clinical and experimental studies. 7788959 - Does injectable gold retard radiologic evidence of joint damage in psoriatic arthritis? 3184069 - The value of the joint alignment and motion scale in rheumatoid arthritis. 8912479 - The prognosis of rheumatoid arthritis. 850779 - Chemical synovectomy with varicocid in rheumatoid arthritis--further results. 9681309 - "not so immediate" hypersensitivity--the danger of biphasic anaphylactic reactions. 8464959 - Decreased heart rate variability in panic disorder patients: a study of power-spectral ... 2762009 - Voiding dysfunction in patients with human t-lymphotropic virus type-1-associated myelo... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-1 |
Journal Detail:
|
Title: Bone Volume: - ISSN: 1873-2763 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8504048 Medline TA: Bone Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010. Published by Elsevier Inc. |
Affiliation:
|
Department of Respiratory Medicine, and Tuberculosis, P.J. Safarik University and L. Pasteur University Hospital, Kosice, Slovakia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cementum- and Periodontal Ligament-like Tissue Formation by Dental Follicle Cell Sheets Co-cultured ...
Next Document: Computational finite element bone mechanics accurately predicts mechanical competence in the human r...