Document Detail

Relationship between occupational social class and exposure to organochlorine pesticides during pregnancy.
MedLine Citation:
PMID:  21435678     Owner:  NLM     Status:  Publisher    
BACKGROUND: Little evidence is available on the influence of socioeconomic factors on exposure to persistent organic pollutants, especially during vulnerable periods such as pregnancy and early life. OBJECTIVE: To investigate the relationship of maternal social class with placental concentrations of organochlorine pesticides (OCPs) and their combined estrogenic activity measured with a biomarker of exposure. METHODS: Exposure to 16 OCPs (DDTs, endosulfans, and seven other compounds) and the total effective xenoestrogenic burden (TEXB) were analyzed in placentas from a mother-child cohort. OCP concentrations were quantified by gas chromatography and mass spectrometry, and TEXB was assessed with the E-Screen bioassay. Social class was classified according to maternal occupation. Multivariate regression analysis was conducted to examine variations in pesticide exposure and TEXB as a function of maternal social class in 257 subjects. RESULTS: Placental p,p'-DDT concentrations were higher in social classes III and IV than in classes I-II (the most affluent); concentrations of the sum of DDTs were higher in class IV; and exposure to the sum of endosulfans was greater in class III. HCB concentrations were higher among women in class IV than in classes I-II and among manual (classes III-V) than non-manual workers. However, the trend across social classes was only statistically significant for HCB. Social class significantly explained 10% of the variability in concentrations of the sum of endosulfans. CONCLUSION: There is a need to explore whether more disadvantaged populations suffer higher levels of exposure to pesticides or other environmental chemicals and how different social processes contribute to this exposure.
Carmen Freire; Esperanza Amaya; Mariana F Fernández; M Carmen González-Galarzo; Rosa Ramos; Jose M Molina-Molina; Juan P Arrebola; Nicolas Olea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Chemosphere     Volume:  -     ISSN:  1879-1298     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), Av. Madrid s/n, 18071 Granada, Spain.
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