Document Detail

Relationship between nocturnal blood pressure variation and silent cerebral infarction in Chinese hypertensive patients.
MedLine Citation:
PMID:  20439107     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: To investigate the relationship between nocturnal blood pressure (BP) variation and silent cerebral infarction (SCI) in hypertensive patients. METHODS: We retrospectively collected demographic, clinical, and laboratory data from 188 Chinese hypertensive patients (111 with SCI, 77 with non-SCI) and analyzed nocturnal BP variation in the SCI and non-SCI patients. Multiple logistic regression was used for analysis. RESULTS: We found that both single and multiple SCI were more common in nondipping patients than dipping patients. In further analysis comparing the SCI group with the non-SCI group, we found that carotid artery plaques and duration of hypertension were independent risk factors of SCI (p<0.05). The nocturnal BP fall (r=-10.614, p=0.000) was also found to be negatively correlated with SCI in our study. In addition, the prevalence of nondipping was not different between the users of three different classes of antihypertensive drugs. CONCLUSION: Our ambulatory blood pressure monitoring study suggested that nondipping was associated with both single and multiple SCI. Abnormal circadian blood pressure rhythm, a parameter in evaluating injury of brain blood vessels, might be a risk factor of SCI.
J F Ma; J L Sun; J Zhao; X Wei; B S Wang; Y Fu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-02
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  294     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  67-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Blood Pressure*
Brain Infarction / blood,  physiopathology*
Carotid Arteries / pathology
Carotid Artery Diseases / blood,  physiopathology
Circadian Rhythm
Intracranial Hypertension / blood,  drug therapy,  physiopathology*
Logistic Models
Middle Aged
Retrospective Studies
Risk Factors
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents

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