Document Detail

Relationship between no-reflow phenomenon and serotonin levels in patients with acute ST-elevation myocardial infarction who underwent primary percutaneous intervention.
MedLine Citation:
PMID:  20538561     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our aim was to investigate the effects of serotonin, which is a severe vasoconstrictor agent, on the occurrence of no-reflow phenomenon. METHODS: In this cross-sectional controlled study, 40 patients, admitted to our clinic with chest pain in the first 12 hours and underwent primary percutaneous coronary intervention because of acute myocardial infarction were enrolled. Patients with TIMI 0 grade basal flow and normal post-procedure flow were included in group 1 and patients with flow grade TIMI < or =were enrolled in group 2. To measure the serotonin levels, blood samples were collected from the coronary ostium before the procedure. RESULTS: In group 1, there were 25 patients (20 males, 5 females) and the mean age was 58+/-11 years; in group 2 there were 15 patients (13 males, 2 females) and the mean age was 62+/-8 years. The mean serotonin level in platelet in group 1 was 476+/-208 ng/109 platelet and in group 2-542+/-273 ng/109 platelet. The difference was not statistically significant (p=0.39). When we compared the serum serotonin levels, it was 41.4+/-40.8 ng/ml for group 1, but 66.7+/-45.7 ng/ml for group 2. Although the serum serotonin levels were higher in group 2, the difference was not statistically significant (p=0.07). CONCLUSION: There was no effect of serotonin level in the development of no-reflow, in patients to whom primary coronary percutaneous intervention was applied.
Ramazan Topsakal; Mehmet G Kaya; Ekrem Karakaya; Ozgür Günebakmaz; Ali Doğan; M Tuğrul Inanç; Bahadir Sarli; Ibrahim Ozdoğru; Ali Ergin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology     Volume:  10     ISSN:  1308-0032     ISO Abbreviation:  Anadolu Kardiyol Derg     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101095069     Medline TA:  Anadolu Kardiyol Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  253-9     Citation Subset:  IM    
Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Blood Flow Velocity
Blood Platelets / metabolism
C-Reactive Protein / metabolism
Chest Pain / etiology
Creatine Kinase / blood
Cross-Sectional Studies
Disease Models, Animal
Middle Aged
Myocardial Infarction / blood*,  therapy
Patient Selection
Serotonin / blood*
Troponin / blood
Vasoconstriction / physiology
Reg. No./Substance:
0/Troponin; 50-67-9/Serotonin; 9007-41-4/C-Reactive Protein; EC Kinase
Comment In:
Anadolu Kardiyol Derg. 2010 Jun;10(3):260-2   [PMID:  20538562 ]

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