Document Detail


Relationship between the neonatal white blood cell count and histologic chorioamnionitis in preterm newborns.
MedLine Citation:
PMID:  22813065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim was to examine the relationship between neonatal white blood cell (WBC) count and the diagnosis of histologic chorioamnionitis (HCA).
DESIGN: We measured WBC, a widely used marker of inflammation, to evaluate whether the values at birth were associated with HCA.
SETTING: NICU, Department of Pediatrics of Padua University, Padua, Italy.
SUBJECTS: WBC count was evaluated in 71 preterm neonates (<32 weeks of gestation) with HCA and in a control group without HCA on day 1, 3, and 6 after delivery. Logistic regression analysis and diagnostic accuracy analysis were used to assess the association between WBC counts and HCA.
MAIN RESULTS: WBC levels were significantly higher in infants with HCA than in those without HCA (Median IQR, WBC (x10(9)/l): day 1, 13.2 (6.2-21.8) vs 8.1 (6-11.4), p < 0.001; day 3, 17.4 (11.4-26.9) vs 6.3 (5.2-8.3), p < 0.001; day 6, 18.4 (11.1-31) vs 6.5 (4.4-9), p < 0.0001). The neonatal WBC count on the third day of life was the most sensitive parameter associated with HCA (sensitivity: 0.80; specificity: 0.88). The cut-off value based on the ROC curve was 10 (x10(9)/l).
CONCLUSIONS: WBC count in the third day of life is strongly associated with HCA.
Authors:
Vincenzo Zanardo; Carla Peruzzetto; Daniele Trevisanuto; Francesco Cavallin; Stefania Vedovato; Gianluca Straface; Silvia Chiarelli
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2012-08-22
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-27     Completed Date:  2013-05-30     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  2769-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Chorioamnionitis / blood*,  diagnosis*,  pathology
Female
Histological Techniques
Humans
Infant, Newborn / blood*
Infant, Premature / blood*
Leukocyte Count
Male
Pregnancy
Prenatal Exposure Delayed Effects / blood*
Prognosis
ROC Curve
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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