Document Detail

Relationship between the neonatal white blood cell count and histologic chorioamnionitis in preterm newborns.
MedLine Citation:
PMID:  22813065     Owner:  NLM     Status:  Publisher    
Abstract Objective: The aim was to examine the relationship between neonatal WBC count and the diagnosis of histologic chorioamnionitis (HCA). Design: We measured WBC, a widely used marker of inflammation, to evaluate whether the values at birth were associated with HCA. Setting: NICU: Department of Pediatrics of Padua University, Padua (Italy) Subjects: WBC count was evaluated In 71 preterm neonates (<32 weeks of gestation) with HCA and in a control group without HCA on day 1, 3, and 6 after delivery. Logistic regression analysis and diagnostic accuracy analysis were used to assess the association between WBC counts and HCA. Main results: WBC levels were significantly higher in infants with HCA than in those without HCA (Median IQR, WBC (x10(9)/l): day 1, 13.2 (6.2-21.8) vs 8.1 (6-11.4), p< 0.001; day 3, 17.4 (11.4-26.9) vs 6.3 (5.2-8.3), p< 0.001; day 6, 18.4 (11.1-31) vs 6.5 (4.4-9), p< 0.0001). The neonatal WBC count on the third day of life was the most sensitive parameter associated with HCA (sensitivity, 0.80, specificity 0.88). The cut-off value based on the ROC curve was 10 (x10(9)/L). Conclusions: WBC count in the third day of life is strongly associated with HCA.
Vincenzo Zanardo; Carla Peruzzetto; Daniele Trevisanuto; Francesco Cavallin; Stefania Vedovato; Gianluca Straface; Silvia Chiarelli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-20
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics, Policlinico Abano Terme, Abano Terme, Italy.
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