Document Detail


Relationship between mutations in HIV-1 RNase H domain and nucleoside reverse transcriptase inhibitors resistance mutations in naïve and pre-treated HIV infected patients.
MedLine Citation:
PMID:  17245724     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent studies have highlighted the need of investigating the in vivo role of ribonuclease H (RNase H) in nucleoside reverse transcriptase inhibitors (NRTIs) resistance. The prevalence of RNase H mutations in naive and in NRTI pre-treated patients in regimen failure were compared and some specific associations between NRTI resistance mutations and RNase H mutations were determined. Four positions were mutated more frequently in pre-treated patients than in naive patients: L469T/I/M/H, T470P/S/E/K, A554T/L/K, and K558R/G/E. Mutations at position K558 were also associated with the number of thymidine analog mutations (TAMs). These results suggest that these mutations could play a role in NRTI resistance.
Authors:
Bénédicte Roquebert; Marc Wirden; Anne Simon; Jérome Deval; Christine Katlama; Vincent Calvez; Anne-Geneviève Marcelin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of medical virology     Volume:  79     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  207-11     Citation Subset:  IM    
Affiliation:
Department of Virology, Pitié-Salpêtrière Hospital and UPRES EA 2387, Université Pierre et Marie Curie, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Substitution / genetics
Anti-HIV Agents / pharmacology*
Drug Resistance, Viral / genetics*
HIV Infections / drug therapy,  virology*
HIV Reverse Transcriptase / drug effects,  genetics*
HIV-1 / drug effects*,  genetics
Humans
Models, Molecular
Mutation, Missense*
Protein Subunits / drug effects,  genetics
Reverse Transcriptase Inhibitors / pharmacology*
Ribonuclease H / drug effects,  genetics
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 0/Protein Subunits; 0/Reverse Transcriptase Inhibitors; EC 2.7.7.49/HIV Reverse Transcriptase; EC 3.1.26.4/Ribonuclease H

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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